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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
ITPA and SLC29A1 Genotyping for the Prediction of Ribavirin Dose Reduction in Anti-HCV Triple Therapy with Protease Inhibitors
Pharmacology, Volume 96, No. 3-4, Year 2015
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Description
Chronic hepatitis C is one of the most important causes of liver disease, leading to cirrhosis, hepatic decompensation and hepatocellular carcinoma. Recently some important advances in therapy have been achieved with the introduction of first wave, first generation direct acting antiviral agents (DAAs) such as boceprevir (BOC), in combination with pegylated interferon (Peg-IFN) and ribavirin (RBV). The superior rate of sustained virological response with this treatment is accompanied by an elevated frequency of anaemia. Several studies have evidenced the importance of single nucleotide polymorphisms (SNPs) in inosine triphosphatase (ITPA) and solute carrier family 29, member 1 (SLC29A1) genes in the development of this adverse event. Here, we investigated haemoglobin levels and the best-known functional SNPs in ITPA and SLC29A1 genes in 22 patients treated with triple therapy with BOC/Peg-IFN/RBV. The identification of ITPA protective and SLC29A1 risk genotypes still appears to be a current methodology in RBV dosing during hepatitis C virus therapy with DAAs. © 2015 S. Karger AG, Basel.
Authors & Co-Authors
Landonio, Simona
Unknown Affiliation
Magni, Carlo Federico
Unknown Affiliation
Mazzali, Cristina
Italy, Milan
Università Degli Studi Di Milano
Italy, Milan
Politecnico Di Milano
Rizzardini, Giuliano
Unknown Affiliation
Clementi, Emilio Giuseppe Ignazio
Italy, Pisa
Institute of Neuroscience, Pisa
Italy, Bosisio Parini
Irccs Eugenio Medea
Statistics
Citations: 2
Authors: 5
Affiliations: 6
Identifiers
Doi:
10.1159/000438486
ISSN:
00317012
Research Areas
Cancer
Infectious Diseases