Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
2-nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia
Bioconjugate Chemistry, Volume 23, No. 3, Year 2012
Notification
URL copied to clipboard!
Description
We developed a novel near-infrared (NIR) fluorescent probe, GPU-167, for in vivo imaging of tumor hypoxia. GPU-167 comprises a tricarbocyanine dye as an NIR fluorophore and two 2-nitroimidazole moieties as exogenous hypoxia markers that undergo bioreductive activation and then selective entrapment in hypoxic cells. After treatment with GPU-167, tumor cells contained significantly higher levels of fluorescence in hypoxia than in normoxia. In vivo fluorescence imaging specifically detected GPU-167 in tumors 24 h after administration. Ex vivo analysis revealed that fluorescence showed a strong correlation with hypoxia inducible factor (HIF)-1 active hypoxic regions. These data suggest that GPU-167 is a promising in vivo optical imaging probe for tumor hypoxia. © 2012 American Chemical Society.
Authors & Co-Authors
Okuda, Kensuke
Japan, Gifu
Gifu Pharmaceutical University
Okabe, Yasuyuki
Japan, Gifu
Gifu Pharmaceutical University
Kadonosono, Tetsuya
Japan, Tokyo
Tokyo Institute of Technology
Ueno, Takahiro
Japan, Gifu
Gifu Pharmaceutical University
Youssif, Bahaa G.M.
Japan, Gifu
Gifu Pharmaceutical University
Kizaka-Kondoh, Shinae
Japan, Tokyo
Tokyo Institute of Technology
Nagasawa, Hideko
Japan, Gifu
Gifu Pharmaceutical University
Statistics
Citations: 149
Authors: 7
Affiliations: 2
Identifiers
Doi:
10.1021/bc2004704
ISSN:
10431802
Research Areas
Cancer