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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Antiprotozoal activity of chloroquinoline based chalcones
European Journal of Medicinal Chemistry, Volume 46, No. 5, Year 2011
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Description
A new series of chloroquinoline based chalcones were synthesized and evaluated for in vitro antiamoebic and antimalarial activities. The results showed that out of fifteen compounds, four were found to be more active against the Entamoeba histolytica; while one compound was moderatively active compared to the standard drug metronidazole (IC50 = 1.46 μM). In contrast, in vitro antimalarial activity against the chloroquine-sensitive (3D7) strain of P. falciparum indicated relatively low activity when compared to controls such as chloroquine and quinine (IC50 = 0.0065 μM and 0.14 μM, respectively). The toxicological studies of these compounds on human breast cancer MCF-7 cell line showed that all the compounds were non-toxic at the concentration range of 1.56-50 μM. © 2011 Elsevier Masson SAS. All rights reserved.
Authors & Co-Authors
Hayat, Faisal
India, New Delhi
Jamia Millia Islamia
Moseley, Emma
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Salahuddin, Attar
India, New Delhi
Jamia Millia Islamia
van Zyl, Robyn Lynne
South Africa, Johannesburg
University of the Witwatersrand Faculty of Health Sciences
Azam, Amir
India, New Delhi
Jamia Millia Islamia
Statistics
Citations: 89
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.ejmech.2011.02.004
ISSN:
02235234
e-ISSN:
17683254
Research Areas
Cancer
Environmental