Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa
Human Molecular Genetics, Volume 18, No. 2, Year 2009
Notification
URL copied to clipboard!
Description
Current endeavour focuses on human genetic factors that contribute to susceptibility to or protection from tuberculosis (TB). Monocytes are crucial in containing Mycobacterium tuberculosis infection, and the monocyte chemoattractant protein-1 (MCP-1) cytokine plays a role in their recruitment to the site of infection. The G allele of the MCP-1 promoter polymorphism at position -2581 relative to the ATG transcription start codon has been described to be associated in Mexican and Korean TB patients with increased susceptibility to TB. We genotyped this and additional MCP-1 variants in sample collections comprising more than 2000 cases with pulmonary TB and more than 2300 healthy controls and 332 affected nuclear families from Ghana, West Africa, and more than 1400 TB patients and more than 1500 controls from Russia. In striking contrast to previous reports, MCP-1 -2581G was significantly associated with resistance to TB in cases versus controls [odds ratio (OR) 0.81, corrected P-value (Pcorr) = 0.0012] and nuclear families (OR 0.72, Pcorr = 0.04) and not with disease susceptibility, whereas in the Russian sample no evidence of association was found (P = 0.86). Our and other results do not support an association of MCP-1 -2581 with TB. In the Ghanaian population, eight additional MCP-1 polymorphisms were genotyped. MCP-1 -362C was associated with resistance to TB in the case-control collection (OR 0.83, Pcorr = 0.00017) and in the affected families (OR 0.7, Pcorr = 0.004). Linkage disequilibrium (LD) and logistic regression analyses indicate that, in Ghanaians, the effect results exclusively from the MCP-1 -362 variant, whereas the effect of -2581 may in part be explained by its LD with -362. © The Author 2008. Published by Oxford University Press. All rights reserved.
Authors & Co-Authors
Thye, Thorsten
Unknown Affiliation
Nejentsev, Sergey
Unknown Affiliation
Intemann, Christopher D.
Unknown Affiliation
Browne, Edmund Nii Laryea
Unknown Affiliation
Chinbuah, Margaret Amanua
Unknown Affiliation
Gyapong, John O.
Unknown Affiliation
Osei, Ivy Frances
Unknown Affiliation
Owusu-Dabo, Ellis
Unknown Affiliation
Zeitels, Lauren R.
Unknown Affiliation
Herb, Florian
Unknown Affiliation
Horstmann, Rolf Dieter
Unknown Affiliation
Meyer, Christian G.
Unknown Affiliation
Statistics
Citations: 77
Authors: 12
Affiliations: 8
Identifiers
Doi:
10.1093/hmg/ddn352
ISSN:
09646906
e-ISSN:
14602083
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Multi-countries
Ghana