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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Effect of Lycopene and Rosmarinic Acid on Gentamicin Induced Renal Cortical Oxidative Stress, Apoptosis, and Autophagy in Adult Male Albino Rat
Anatomical Record, Volume 300, No. 6, Year 2017
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Description
Gentamicin nephrotoxicity accounts for 10%–15% of all cases of acute renal failure. Several natural antioxidants were found to be effective against drug-induced toxicity. The possible protective effects of lycopene (Lyc) and rosmarinic acid (RA) alone or combined on gentamicin (Gen) induced renal cortical oxidative stress, apoptosis, and autophagy were evaluated. Sixty-three rats were randomly divided into seven groups named: control, group II received RA 50 mg/kg/day, group III received Lyc 4 mg/kg/day, group IV received Gen 100 mg/kg/day, group V (RA + Gen), group VI (Lyc + Gen), and group VII (RA + Lyc + Gen). At the end of the experiment, kidney functions were estimated then the kidneys were sampled for histopathological, immunohistochemistry, and biochemical studies. Administration of rosmarinic acid and lycopene decreased elevated serum creatinine, blood urea nitrogen, renal malondialdehyde and immunoexpression of the proapoptotic protein (Bax), autophagic marker protein (LC3/B), and inducible nitric oxide synthase (iNOS) induced by gentamicin. They increased reduced glutathione, glutathione peroxidase, superoxide dismutase, and immunoexpression of the antiapoptotic protein (Bcl2). They also improved the histopathological changes induced by gentamicin. The combination therapy of rosmarinic acid and lycopene shows better protective effects than the corresponding monotherapy. Anat Rec, 300:1137–1149, 2017. © 2016 Wiley Periodicals, Inc.
Authors & Co-Authors
Bayomy, Naglaa A.
Egypt, Tanta
Faculty of Medicine
El-Bakary, Reda Hassan
Egypt, Tanta
Faculty of Medicine
Ibrahim, Marwa A.A.
Egypt, Tanta
Faculty of Medicine
Abdelaziz, Eman Z.
Egypt, Ismailia
Faculty of Medicine
Statistics
Citations: 41
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1002/ar.23525
ISSN:
19328486
e-ISSN:
19328494
Research Areas
Cancer
Study Approach
Quantitative
Participants Gender
Male