Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Area of exposure and treatment challenges of malaria in Eritrean migrants: A GeoSentinel analysis
Malaria Journal, Volume 17, No. 1, Article 443, Year 2018
Notification
URL copied to clipboard!
Description
Background: Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature review to elucidate key attributes of malaria in this group with a focus on possible areas of acquisition of malaria and treatment challenges. Results: A total of 146 cases were identified from the GeoSentinel database from 1999 through September 2017, with a marked increase in 2014 and 2015. All patients originated from Eritrea and the main reporting GeoSentinel sites were in Norway, Switzerland, Sweden, Israel and Germany. The majority of patients (young adult males) were diagnosed with malaria following arrival in the host country. All patients had a possible exposure in Eritrea, but may have been exposed in documented transit countries including Ethiopia, Sudan and possibly Libya in detention centres. Most infections were due to Plasmodium vivax (84.2%), followed by Plasmodium falciparum (8.2%). Two patients were pregnant, and both had P. vivax malaria. Some 31% of the migrants reported having had malaria while in transit. The median time to onset of malaria symptoms post arrival in the host country was 39 days. Some 66% of patients were hospitalized and nine patients had severe malaria (according to WHO criteria), including five due to P. vivax. Conclusions: The 146 cases of mainly late onset, sometimes severe, P. vivax malaria in Eritrean migrants described in this multi-site, global analysis reflect the findings of single-centre analyses identified in the literature search. Host countries receiving asylum-seekers from Eritrea need to be prepared for large surges in vivax and, to a lesser extent, falciparum malaria, and need to be aware and prepared for glucose-6-phosphate dehydrogenase deficiency testing and primaquine treatment, which is difficult to procure and mainly unlicensed in Europe. There is an urgent need to explore the molecular epidemiology of P. vivax in Eritrean asylum-seekers, to investigate the area of acquisition of P. vivax along common transit routes and to determine whether there has been re-introduction of malaria in areas, such as Libya, where malaria is considered eliminated, but where capable vectors and Plasmodium co-circulate. © 2018 The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6267801/bin/12936_2018_2586_MOESM1_ESM.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6267801/bin/12936_2018_2586_MOESM2_ESM.docx
Authors & Co-Authors
Schlagenhauf, Patricia
Switzerland, Zurich
Universität Zürich
Grobusch, Martín Peter
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Hamer, Davidson Howes
United States, Boston
Boston University Chobanian & Avedisian School of Medicine
Ásgeirsson, Hilmir
Sweden, Stockholm
Karolinska Universitetssjukhuset
Sweden, Stockholm
Karolinska Institutet
Jensenius, Mogens
Norway, Oslo
Oslo Universitetssykehus
Eperon, Gilles A.
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Rothe, Camilla
Germany, Munich
Klinikum Der Universität München
Fehr, Jan Sven
Switzerland, Zurich
Universität Zürich
Schwartz, Eli N.
Israel, Tel Hashomer Tel Aviv
Chaim Sheba Medical Center Israel
Bottieau, Emmanuel
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Barnett, Elizabeth D.
United States, Boston
Boston Medical Center
McCarthy, Anne E.
Canada, Ottawa
University of Ottawa
Kelly, Paul J.
United States, New York
Bronx-lebanon Hospital Center
Larsen, Carsten Schade
Denmark, Aarhus
Aarhus Universitetshospital
van Genderen, Perry J.J.
Netherlands, Rotterdam
Harbour Hospital
Stauffer, William M.
United States, Minneapolis
University of Minnesota Twin Cities
Libman, Michael D.
Canada, Montreal
Université Mcgill
Gautret, Philippe
France, Marseille
Aix Marseille Université
Statistics
Citations: 14
Authors: 18
Affiliations: 18
Identifiers
Doi:
10.1186/s12936-018-2586-9
ISSN:
14752875
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Systematic review
Study Locations
Eritrea
Ethiopia
Libya
Sudan