Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Integrated genomic surveillance enables tracing of person-to-person SARS-CoV-2 transmission chains during community transmission and reveals extensive onward transmission of travel-imported infections, Germany, June to July 2021
Eurosurveillance, Volume 27, No. 43, Year 2022
Notification
URL copied to clipboard!
Description
Background: Tracking person-to-person SARS-CoV-2 transmission in the population is important to understand the epidemiology of community transmission and may contribute to the containment of SARS-CoV-2. Neither contact tracing nor genomic surveillance alone, however, are typically sufficient to achieve this objective. Aim: We demonstrate the successful application of the integrated genomic surveillance (IGS) system of the German city of Düsseldorf for tracing SARS-CoV-2 transmission chains in the population as well as detecting and investigating travel-associated SARS-CoV-2 infection clusters. Methods: Genomic surveillance, phylogenetic analysis, and structured case interviews were integrated to elucidate two genetically defined clusters of SARS-CoV-2 isolates detected by IGS in Düsseldorf in July 2021. Results: Cluster 1 (n=67 Düsseldorf cases) and Cluster 2 (n=36) were detected in a surveillance dataset of 518 high-quality SARS-CoV-2 genomes from Düsseldorf (53% of total cases, sampled mid-June to July 2021). Cluster 1 could be traced back to a complex pattern of transmission in nightlife venues following a putative importation by a SARS-CoV-2-infected return traveller (IP) in late June; 28 SARS-CoV-2 cases could be epidemiologically directly linked to IP. Supported by viral genome data from Spain, Cluster 2 was shown to represent multiple independent introduction events of a viral strain circulating in Catalonia and other European countries, followed by diffuse community transmission in Düsseldorf. Conclusion: IGS enabled high-resolution tracing of SARS-CoV-2 transmission in an internationally connected city during community transmission and provided infection chain-level evidence of the downstream propagation of travel-imported SARS-CoV-2 cases. © 2022 European Centre for Disease Prevention and Control (ECDC). All rights reserved.
Authors & Co-Authors
Ciruela, Pilar
Spain, Barcelona
Agencia de Salut Publica de Barcelona
Spain, Madrid
Instituto de Salud Carlos Iii
Wienemann, Tobias
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Lübke, Nadine
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Göbels, Klaus
Unknown Affiliation
Pfeffer, Klaus
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Timm, Joerg
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Walker, Andreas
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Dilthey, Alexander T.
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Altmüller, Janine
Unknown Affiliation
Angelov, Angel
Unknown Affiliation
Aschenbrenner, Anna C.
Unknown Affiliation
Bals, Robert
Unknown Affiliation
Becker, Anke
Unknown Affiliation
Bezdan, Daniela
Unknown Affiliation
Bitzer, Michael
Unknown Affiliation
Bonifacio, Ezio E.
Unknown Affiliation
Bork, Peer
Unknown Affiliation
Blum, Helmut
Unknown Affiliation
Casadei, Nicolas L.P.
Unknown Affiliation
Clavel, Thomas
Unknown Affiliation
Cornberg, Markus
Unknown Affiliation
De La Rosa-Velazquez, Inti Alberto
Unknown Affiliation
Diefenbach, Andreas
Unknown Affiliation
Fischer, Nicole
Unknown Affiliation
Förstner, Konrad U.
Unknown Affiliation
Ganzenmueller, Tina
Unknown Affiliation
Goesmann, Alexander
Unknown Affiliation
Göpel, Siri
Unknown Affiliation
Grundhoff, Adam T.
Unknown Affiliation
Grundmann, Hajo J.
Unknown Affiliation
Hain, Torsten
Unknown Affiliation
Hanses, Frank
Unknown Affiliation
Hehr, Ute
Unknown Affiliation
Hübschmann, Daniel
Unknown Affiliation
Hummel, Michael
Unknown Affiliation
Iftner, Thomas
Unknown Affiliation
Illig, Thomas
Unknown Affiliation
Janssen, Stefan
Unknown Affiliation
Kalinowski, Jörn
Unknown Affiliation
Kallies, René
Unknown Affiliation
Keller, Andreas C.
Unknown Affiliation
Keppler, Oliver Till
Unknown Affiliation
Klein, Christoph A.
Unknown Affiliation
Korbel, Jan O.
Unknown Affiliation
Kremsner, Peter Gottfried
Unknown Affiliation
Kühnert, Denise
Unknown Affiliation
Kurth, Ingo
Unknown Affiliation
Ludwig, Kerstin Urte
Unknown Affiliation
Makarewicz, Oliwia
Unknown Affiliation
Marz, Manja
Unknown Affiliation
McHardy, Alice Carolyn
Unknown Affiliation
Nahnsen, Sven
Unknown Affiliation
Nöthen, Markus Maria
Unknown Affiliation
Ntoumi, Francine
Unknown Affiliation
Nurnberg, Peter N.
Unknown Affiliation
Ossowski, Stephan
Unknown Affiliation
Overmann, Jörg
Unknown Affiliation
Peter, Silke
Unknown Affiliation
Pink, Isabell
Unknown Affiliation
Protzer, Ulrike
Unknown Affiliation
Ralser, Markus
Unknown Affiliation
Riess, Olaf H.
Unknown Affiliation
Ripke, Stephan
Unknown Affiliation
Rocha, Ulisses
Unknown Affiliation
Rosenstiel, Philip C.
Unknown Affiliation
Scheithauer, Simone
Unknown Affiliation
Schmid-Burgk, Jonathan Leo
Unknown Affiliation
Sczyrba, Alexander
Unknown Affiliation
Singh, Yogesh
Unknown Affiliation
Sonnabend, Michael S.
Unknown Affiliation
Stegle, Oliver
Unknown Affiliation
Stoye, Jens
Unknown Affiliation
Theis, Fabian J.
Unknown Affiliation
Ulas, Thomas
Unknown Affiliation
Vehreschild, Jörg Janne
Unknown Affiliation
Velavan, Thirumalaisamy P.
Unknown Affiliation
Walter, Jörn E.
Unknown Affiliation
Wieczorek, Dagmar
Unknown Affiliation
Ziebuhr, John
Unknown Affiliation
Statistics
Citations: 4
Authors: 79
Affiliations: 6
Identifiers
Doi:
10.2807/1560-7917.ES.2022.27.43.2101089
ISSN:
1025496X
Study Design
Cross Sectional Study