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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Common and diverse features of cocirculating type 2 and 3 recombinant vaccine-derived polioviruses isolated from patients with poliomyelitis and healthy children
Journal of Infectious Diseases, Volume 205, No. 9, Year 2012
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Description
Background. Five cases of poliomyelitis due to type 2 or 3 recombinant vaccine-derived polioviruses (VDPVs) were reported in the Toliara province of Madagascar in 2005. Methods. We sequenced the genome of the VDPVs isolated from the patients and from 12 healthy children and characterized phenotypic aspects, including pathogenicity, in mice transgenic for the poliovirus receptor.Results.We identified 6 highly complex mosaic recombinant lineages composed of sequences derived from different vaccine polioviruses and other species C human enteroviruses (HEV-Cs). Most had some recombinant genome features in common and contained nucleotide sequences closely related to certain cocirculating coxsackie A virus isolates. However, they differed in terms of their recombinant characteristics or nucleotide substitutions and phenotypic features. All VDPVs were neurovirulent in mice.Conclusions.This study confirms the genetic relationship between type 2 and 3 VDPVs, indicating that both types can be involved in a single outbreak of disease. Our results highlight the various ways in which a vaccine-derived poliovirus may become pathogenic in complex viral ecosystems, through frequent recombination events and mutations. Intertypic recombination between cocirculating HEV-Cs (including polioviruses) appears to be a common mechanism of genetic plasticity underlying transverse genetic variability. © 2012 The Author.
Authors & Co-Authors
Joffret, Marie Line
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Jegouic, Sophie
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Bessaud, Maël
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
France, Marseille
Émergence Des Pathologies Virales
Balanant, Jean G.
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Tran, Coralie
France, Paris
Institut Pasteur, Paris
Caro, Valérie
France, Paris
Institut Pasteur, Paris
Holmblat, Barbara
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
France, Paris
Université Paris Cité
Razafindratsimandresy, Richter
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Reynes, Jean Marc
Madagascar, Antananarivo
Institut Pasteur de Madagascar
France, Lyon
’unité de Biologie Des Infections Virales Emergentes
Rakoto-Andrianarivelo, Mala
France, Paris
Université Paris Cité
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Switzerland, Geneva
Organisation Mondiale de la Santé
Delpeyroux, Francis
France, Paris
Institut Pasteur, Paris
France, Paris
Inserm
Statistics
Citations: 43
Authors: 11
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jis204
ISSN:
00221899
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Locations
Madagascar