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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Carcinoembryonic antigen admittance biosensor based on Au and ZnO nanoparticles using FFT admittance voltammetry
Analytical Chemistry, Volume 83, No. 5, Year 2011
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Description
In this work, a highly sensitive carcinoembryonic antigen fast Fourier transform admittance biosensor is introduced. The proposed biosensor is based on bilayer films of ZnO/Au nanoparticles as an immobilization matrix. These layers are prepared by self-assembly and deposition method on a gold electrode surface, respectively. Carcinoembryonic antibody (anti-CEA) was immobilized on gold nanoparticles and positively charged horseradish peroxidase (HRP) was used to block sites against nonspecific binding. The admittance biosensor was developed based on fast Fourier transform continuous square wave voltammetry, which produces a sensitive, fast (less than 20 s) and reliable response for determination of carcinoembryonic antigen. The technique was applied as a detector in a flow injection system. The admittances reduction current of the biosensor decreases linearly in two concentrations ranges of CEA from 0.1 to 70 ng/mL and from 70 to 200 ng/mL with a detection limit of 0.01 ng/mL in presence of 0.5 mM H2O2 as an eluent solution. © 2011 American Chemical Society.
Authors & Co-Authors
Norouzi, Parviz
Iran, Tehran
University of Tehran
Iran, Tehran
Endocrinology and Metabolism Research Institute Tums
Gupta, Vinod Kumar
India, Roorkee
Indian Institute of Technology Roorkee
Saudi Arabia, Dhahran
King Fahd University of Petroleum and Minerals
Faridbod, Farnoush
Iran, Tehran
Endocrinology and Metabolism Research Institute Tums
Pirali-Hamedani, Morteza
Iran, Tehran
School of Pharmacy
Iran, Tehran
Pharmaceutical Sciences Research Center Psrc
Larijani, Bagher A.
Iran, Tehran
Endocrinology and Metabolism Research Institute Tums
Ganjali, Mohammad Reza
Iran, Tehran
University of Tehran
Iran, Tehran
Endocrinology and Metabolism Research Institute Tums
Statistics
Citations: 78
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1021/ac102270w