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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly
Journal of Biological Chemistry, Volume 285, No. 14, Year 2010
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Description
Angiogenin (ANG) is a secreted ribonuclease that cleaves tRNA to initiate a stress-response program in mammalian cells. Here we show that ANG inhibits protein synthesis and promotes arsenite- and pateamine A-induced assembly of stress granules (SGs). These effects are abrogated in cells transfected with the ANG inhibitor RNH1. Transfection of natural or synthetic 5′-but not 3′-tRNA fragments (tRNA-derived stress-induced RNAs; tiRNAs) induces the phospho-eukaryotic translation initiation factor 2α-independent assembly of SGs. Natural 5′-tiRNAs but not 3′-tiRNAs are capped with a 5′-monophosphate that is required for optimal SG assembly. These findings reveal that SG assembly is a component of the ANG- and tiRNA-induced stress response program. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2856301/bin/supp_285_14_10959__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2856301/bin/supp_M109.077560_jbc.M109.077560-1.pdf
Authors & Co-Authors
Emara, Mohamed M.
United States, Boston
Brigham and Women's Hospital
Egypt, Giza
Faculty of Veterinary Medicine
Ivanov, Pavel V.
United States, Boston
Brigham and Women's Hospital
Hickman, Tyler T.
United States, Boston
Brigham and Women's Hospital
Dawra, Nemisha
United States, Boston
Brigham and Women's Hospital
Tisdale, Sarah
United States, Boston
Brigham and Women's Hospital
Kedersha, Nancy L.
United States, Boston
Brigham and Women's Hospital
Hu, Guofu
United States, Boston
Harvard Medical School
Anderson, Paul J.
United States, Boston
Brigham and Women's Hospital
Statistics
Citations: 421
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1074/jbc.M109.077560
ISSN:
00219258
e-ISSN:
1083351X