Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: Modulation of T cell proliferation
BMC Complementary and Alternative Medicine, Volume 13, Article 77, Year 2013
Notification
URL copied to clipboard!
Description
Background: Populations in Africa mostly rely on herbal concoctions for their primarily health care, but so far scientific studies supporting the use of plants in traditional medicine remain poor. The present study was undertaken to evaluate the anti-hyperglycemic effects of Picralima nitida (seeds), Nauclea latifolia (root and stem) and Oxytenanthera abyssinica (leaves) commonly used, in diabetic pregnancy.Methods: Pregnant wistar rats, rendered diabetic by multiple low injections of streptozotocin, were treated with selected plant extracts based on their antioxidant activities. Vitamin C concentrations, fatty acid compositions and phytochemical analysis of plants extracts were determined. Effect of selected plant extracts on human T cell proliferation was also analysed.Results: All analysed plant extracts exhibited substantial antioxidant activities probably related to their content in polyphenols. Picralima nitida exhibited the highest antioxidant capacity. Ethanolic and butanolic extracts of Picralima nitida, butanolic extract of Nauclea latifolia and ethanolic extract of Oxytenanthera abyssinica significantly decreased hyperglycemia in the diabetic pregnant rats. Butanolic extract of Picralima, also appeared to be the most potent immunosuppressor although all of the analysed extracts exerted an immunosuppressive effect on T cell proliferation probably due to their linolenic acid (C18:3n-3) and/or alkaloids content. Nevertheless, all analysed plants seemed to be good source of saturated and monounsaturated fatty acids.Conclusion: By having antioxidant, anti-hyperglycemic and immunosuppressive activities, these plants could be good candidates in the treatment of diabetes and diabetic pregnancy. © 2013 Yessoufou et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Yessoufou, Akadiri
Benin, Cotonou
University of Abomey-calavi
Gbénou, Joachim Djimon
Benin, Cotonou
University of Abomey-calavi
Grissa, Oussama
Tunisia, Sousse
Hopital Farhat Hached Sousse
Hichami, Aziz
France, Dijon
Université de Bourgogne
Simonin, Anne Marie
France, Dijon
Université de Bourgogne
Tabka, Zouhaïr
Tunisia, Sousse
Hopital Farhat Hached Sousse
Moudachirou, Mansourou
Benin, Cotonou
University of Abomey-calavi
Moutairou, Kabirou A.
Benin, Cotonou
University of Abomey-calavi
Khan, Naim Akhtar
France, Dijon
Université de Bourgogne
Statistics
Citations: 42
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1186/1472-6882-13-77
e-ISSN:
14726882
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health