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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania
Pediatrics, Volume 117, No. 2, Year 2006
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Description
OBJECTIVES. To determine the association between maternal multivitamin supplementation and the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania, as secondary endpoints in a randomized trial that investigated the effect of maternal multivitamin supplementation on HIV-1 vertical transmission and progression. METHODS. The Bayley Scales of Infant Development, 2nd Edition, were administered at 6, 12, and 18 months of age to a subset of children (N = 327). We assessed the effect of vitamin A and multivitamin (vitamins B, C, and E) supplementation using linear regression models and Cox proportional hazard models for the Mental Development Index, the Psychomotor Development Index, and raw scores separately. RESULTS. Multivitamin supplementation was associated significantly with a mean increase in Psychomotor Development Index score of 2.6 (95% confidence interval: 0.1-5.1). Multivitamins were also significantly protective against the risk for developmental delay on the motor scale (relative risk: 0.4; 95% confidence interval: 0.2- 0.7) but not on the Mental Development Index. Vitamin A supplementation had no significant effect on these outcomes. CONCLUSIONS. Maternal multivitamin supplements provide a low-cost intervention to reduce the risk for developmental delays among infants who are born to HIV-positive mothers in developing countries. Copyright © 2006 by the American Academy of Pediatrics.
Authors & Co-Authors
McGrath, Nuala M.
United States, Boston
Harvard T.h. Chan School of Public Health
Bellinger, David C.
United States, Boston
Boston Children's Hospital
Robins, James M.
United States, Boston
Harvard T.h. Chan School of Public Health
Msamanga, Gernard I.
Tanzania, Dar es Salaam
Muhimbili University of Health and Allied Sciences
Tronick, Edward
United States, Boston
Harvard T.h. Chan School of Public Health
Fawzi, Wafaie W.
United States, Boston
Harvard T.h. Chan School of Public Health
Statistics
Citations: 67
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1542/peds.2004-1668
ISSN:
00314005
e-ISSN:
02105721
Research Areas
Environmental
Infectious Diseases
Maternal And Child Health
Study Design
Randomised Control Trial
Study Locations
Tanzania