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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genotoxic effects of waterpipe smoking on the buccal mucosa cells
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Volume 695, No. 1-2, Year 2008
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Description
Waterpipe smoking is popular in many parts of the world. Micronuclei (MN) evaluation in the exfoliated oral cells of smokers is a non-invasive technique for evaluation of possible tobacco harm. We aimed to assess whether MN levels are higher in waterpipe smokers than in never smokers. We examined oral smears of 128 adult male waterpipe smokers and 78 males who never smoked tobacco in rural Egypt. The total number of MN per 1000 cells per subject, and the number of MN-containing cells per individual were compared. We observed a higher level of total MN in waterpipe smokers (10. ±. 4) than in never smokers (4. ±. 2, . p<. 0.001). A similar difference was found for the mean number of affected cells per individual (8. ±. 3 vs. 4. ±. 1.62, . p<. 0.001). MN levels were not significantly dose related. This study is among the first to assess the association between waterpipe smoking and a cytogenetic measure of tobacco harm. The twofold increase in MN level is consistent with previous reports of MN in cigarette smokers. More research is needed to determine if such MN levels are predictive of future health consequences. © 2008 Elsevier B.V..
Authors & Co-Authors
El-Setouhy, M.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Loffredo, Christopher A.
United States, Washington, D.c.
Georgetown University
Radwan, Ghada Nasr
Egypt, Cairo
Faculty of Medicine
Rahman, Rehab Abdel
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Mahfouz, Eman Mohamed
Egypt, Minya
Faculty of Medicine
Israel, Ebenezer
United States, Baltimore
University of Maryland, Baltimore Umb
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Ayyad, Sohair B.A.
Egypt, Cairo
Ain Shams University Hospitals
Statistics
Citations: 81
Authors: 8
Affiliations: 6
Identifiers
Doi:
10.1016/j.mrgentox.2008.06.014
ISSN:
13835718
e-ISSN:
18793592
Research Areas
Health System And Policy
Substance Abuse
Study Locations
Egypt
Participants Gender
Male