Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Viral and host factors associated with the HIV-1 viral load setpoint in adults from mbeya region, Tanzania
Journal of Acquired Immune Deficiency Syndromes, Volume 54, No. 3, Year 2010
Notification
URL copied to clipboard!
Description
Background: The viral load setpoint (VLS) is an important predictor of HIV disease progression, but there is a lack of information regarding the VLS and its possible determinants in African populations. Methods: Initially HIV-negative adults from 3 distinct groups (female bar workers, females, and males from the general population) were followed for up to 4 years. The VLS was calculated for 108 seroconverters and associations of the VLS with possible risk factors were analyzed using univariate and multivariate regression. Results: The median VLS for female bar workers, females, and males from the general population were 69,850, 28,600, and 158,000 RNA copies per milliliter, respectively. Significant associations with an elevated viral load were observed for male gender [risk ratio (RR) = 1.83, 95% confidence interval (95% CI) = 1.14 to 2.93], the expression of harmful HLA I alleles (RR = 1.73, 95% CI = 1.13 to 2.66) and multiple infection with different HIV-1 subtypes (RR = 1.65, 95% CI = 1.03 to 2.66). Bar workers were considerably more often infected with different HIV-1 subtypes than participants from the general population. Conclusions: Our study confirms that gender and the expression of different HLA class I alleles are important determinants of the viremia at VLS, and it also corroborates an earlier finding that multiple infection with different HIV-1 subtypes is associated with a higher VLS. Copyright © 2010 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Saathoff, Elmar
Unknown Affiliation
Pritsch, Michael
Unknown Affiliation
Geldmacher, Christof
Unknown Affiliation
Hoffmann, Oliver
Unknown Affiliation
Lenzi, Rebecca
Unknown Affiliation
Maboko, Leonard L.
Unknown Affiliation
Maganga, Lucas Henze
Unknown Affiliation
Geis, Steffen
Unknown Affiliation
McCutchan, Francine E.
Unknown Affiliation
Kijak, Gustavo Hernán
Unknown Affiliation
Kim, Jerome Hahn
Unknown Affiliation
Arroyo, Miguel A.
Unknown Affiliation
Gerhardt, Martina
Unknown Affiliation
Tovanabutra, Sodsai
Unknown Affiliation
Robb, Merlin Lee
Unknown Affiliation
Williamson, Carolyn
Unknown Affiliation
Michael, Nelson L.
Unknown Affiliation
Höelscher, Michael
Unknown Affiliation
Statistics
Citations: 18
Authors: 18
Affiliations: 8
Identifiers
Doi:
10.1097/QAI.0b013e3181cf30ba
ISSN:
15254135
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Tanzania
Participants Gender
Male
Female