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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
The high prevalence of subclinical atherosclerosis in patients with ankylosing spondylitis without clinically evident cardiovascular disease
Medicine, Volume 88, No. 6, Year 2009
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Description
We conducted the present study to determine whether subclinical macrovascular atherosclerotic disease was present in patients with ankylosing spondylitis (AS) without clinical history of cardiovascular disease. We also sought to establish whether demographic or clinical features of the disease may influence the development of subclinical atherosclerotic disease in a series of patients with AS seen at a community hospital. We recruited 64 patients who fulfilled the modified New York diagnostic criteria for AS from Hospital Xeral-Calde, Lugo, Spain. We excluded patients seen during the recruitment period who had cardiovascular disease or renal insufficiency. We also studied 64 matched controls. Carotid artery intima-media thickness (IMT) and carotid plaques were measured in the right common carotid artery. The study was performed using high-resolution B-mode ultrasound.Patients with AS exhibited greater carotid IMT than did matched controls (mean ± SD, 0.74 ± 0.21 mm vs. 0.67 ± 0.14 mm; p = 0.01; differences of means, 0.077; 95% confidence interval, 0.016-0.139). Carotid plaques were more commonly observed in patients with AS than in controls (19 [29.7%] vs. 6 [9.4%], respectively; p = 0.03). The best predictors for carotid plaques in patients with AS were erythrocyte sedimentation rate (ESR) at time of disease diagnosis (odds ratio [OR], 1.18; 95% confidence intervals [CI], 1.04-1.33; p = 0.01) and duration of disease (OR, 1.39; 95% CI, 1.01-1.92; p = 0.05). In contrast, there was no significant correlation between carotid IMT and either ESR or C-reactive protein in this study. Results of the present study show that patients with AS without clinically evident cardiovascular disease have a high prevalence of subclinical macrovascular disease in the form of increased carotid IMT and carotid plaques compared to matched controls. Copyright © 2009 by Lippincott Williams & Wilkins.
Authors & Co-Authors
González-Juanatey, Carlos
Unknown Affiliation
Vázquez-Rodríguez, Tomás Ramón
Spain, Lugo
Complejo Hospitalario Xeral Calde
Miranda-Filloy, José Alberto
Spain, Lugo
Complejo Hospitalario Xeral Calde
Dierssen-Sotos, Trinidad
Spain, Santander
Universidad de Cantabria
Blanco-Alonso, Ricardo
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Llorca-Díaz, Javier Francisco
Spain, Santander
Universidad de Cantabria
González-Gay, Miguel Ángel
Spain, Lugo
Complejo Hospitalario Xeral Calde
Statistics
Citations: 137
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1097/MD.0b013e3181c10773
ISSN:
00257974
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study