Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Integrated genomic and molecular characterization of cervical cancer
Nature, Volume 543, No. 7645, Year 2017
Notification
URL copied to clipboard!
Description
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers. © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
Authors & Co-Authors
Burk, Robert David
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Chen, Zigui
United States, New York
Albert Einstein College of Medicine of Yeshiva University
Humberto Fregnani, Jose
Brazil, Barretos
Hospital de Câncer de Barretos
Creighton, Chad J.
United States, Houston
Baylor College of Medicine
Castro, Patricia D.
United States, Houston
Baylor College of Medicine
Wang, Sophia S.
United States, Duarte
City of Hope National Med Center
Yau, Christina
United States, Novato
Buck Institute for Research on Aging
Robertson, Andrew Gordon
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Mungall, Karen L.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Bowlby, Reanne
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Brooks, Denise B.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Mungall, Andrew J.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Schein, Jacqueline E.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Ma, Yussanne P.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Marra, Marco A.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Moore, Richard A.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Jones, Steven J.M.
Canada, Vancouver
Canada‘s Michael Smith Genome Sciences Centre
Seidman, Jonathan G.
United States, Boston
Harvard Medical School
Park, Peter J.
United States, Boston
Harvard Medical School
Borowsky, Mark L.
United States, Wilmington
Christiana Care Health System
Ojesina, Akinyemi I.
United States, Huntsville
Hudsonalpha Institute for Biotechnology
United States, Cambridge
Harvard University
United States, Birmingham
The University of Alabama at Birmingham
Sandusky, George Earl
United States, Indianapolis
Indiana University School of Medicine
Adebamowo, Sally N.
Nigeria, Abuja
Institute of Human Virology - Nigeria
Akeredolu, Teniola
Nigeria, Abuja
Institute of Human Virology - Nigeria
Adebamowo, Clement
Nigeria, Abuja
Institute of Human Virology - Nigeria
Reynolds, Sheila M.
United States, Seattle
Institute for Systems Biology
Shmulevich, Ilya
United States, Seattle
Institute for Systems Biology
Liu, Jia
United States, Reston
Leidos Inc.
Lolla, Laxmi
United States, Reston
Leidos Inc.
Chudamani, Sudha
United States, Reston
Leidos Inc.
Wu, Ye
United States, Reston
Leidos Inc.
Birrer, Michael J.
United States, Boston
Massachusetts General Hospital
Fulton, Robert S.
United States, St. Louis
Washington University in St. Louis
Fronick, Catrina C.
United States, St. Louis
Washington University in St. Louis
Lu, Charles Q.
United States, St. Louis
Washington University in St. Louis
Mardis, Elaine R.
United States, St. Louis
Washington University in St. Louis
Li, Tiandao
United States, St. Louis
Washington University in St. Louis
Wilson, Richard K.
United States, St. Louis
Washington University in St. Louis
Rader, Janet S.
United States, Milwaukee
Medical College of Wisconsin
Wrangle, John M.
United States, Charleston
Medical University of South Carolina
Levine, Douglas A.
United States, New York
Memorial Sloan-kettering Cancer Center
Dao, Fanny
United States, New York
Memorial Sloan-kettering Cancer Center
Schultz, Nikolaus D.
United States, New York
Memorial Sloan-kettering Cancer Center
Einstein, Mark H.
United States, New York
Montefiore Medical Center
Wentzensen, Nicolas A.
United States, Rockville
National Cancer Institute Nci
Felau, Ina
United States, Rockville
National Cancer Institute Nci
Zenklusen, Jean Claude
United States, Rockville
National Cancer Institute Nci
Bodelón, Clara
United States, Rockville
National Cancer Institute Nci
Demchok, John A.
United States, Rockville
National Cancer Institute Nci
Ferguson, Martin L.
United States, Rockville
National Cancer Institute Nci
Tarnuzzer, Roy W.
United States, Rockville
National Cancer Institute Nci
Schiffman, Mark H.
United States, Rockville
National Cancer Institute Nci
Davidsen, Tanja M.
United States, Rockville
National Cancer Institute Nci
Olaniyan, Olayinka Babafemi
Nigeria, Abuja
National Hospital, Abuja
Hutter, Carolyn M.
United States, Bethesda
National Human Genome Research Institute Nhgri
Sofia, Heidi J.
United States, Bethesda
National Human Genome Research Institute Nhgri
Bartlett, John M.S.
Canada, Toronto
Ontario Institute for Cancer Research
Sekhon, Harman S.
Canada, Ottawa
L'hôpital D'ottawa
Gilbert, Sebastien
Canada, Ottawa
L'hôpital D'ottawa
Karlan, Beth Y.
United States, Los Angeles
Cedars-sinai Medical Center
Lester, Jenny
United States, Los Angeles
Cedars-sinai Medical Center
Oršulić, Sandra
United States, Los Angeles
Cedars-sinai Medical Center
Sun, Qiang
United States, Reston
General Dynamics Corporation
Naresh, Rashi
United States, Reston
General Dynamics Corporation
Pihl, Todd D.
United States, Reston
General Dynamics Corporation
Wan, Yunhu
United States, Reston
General Dynamics Corporation
Zhang, Hailei
United States, Cambridge
Harvard University
Cherniack, Andrew D.
United States, Cambridge
Harvard University
Sougnez, Carrie L.
United States, Cambridge
Harvard University
Pedamallu, Chandra Sekhar
United States, Cambridge
Harvard University
Noble, Michael S.
United States, Cambridge
Harvard University
Heiman, David I.
United States, Cambridge
Harvard University
Voet, Doug
United States, Cambridge
Harvard University
Getz, Gad A.
United States, Cambridge
Harvard University
Saksena, Gordon
United States, Cambridge
Harvard University
Kim, Jaegil
United States, Cambridge
Harvard University
Cho, Juok
United States, Cambridge
Harvard University
Lawrence, Michael S.
United States, Cambridge
Harvard University
Gehlenborg, Nils
United States, Cambridge
Harvard University
Lin, Pei
United States, Cambridge
Harvard University
Beroukhim, Rameen
United States, Cambridge
Harvard University
Frazer, Scott
United States, Cambridge
Harvard University
Gabriel, Stacey Bolk
United States, Cambridge
Harvard University
Schumacher, Steven E.
United States, Cambridge
Harvard University
Lichtenberg, Tara M.
United States, Columbus
Research Institute at Nationwide Childrens Hospital
Zmuda, Erik J.
United States, Columbus
Research Institute at Nationwide Childrens Hospital
Bowen, Jay
United States, Columbus
Research Institute at Nationwide Childrens Hospital
Gastier-Foster, Julie M.
United States, Columbus
Research Institute at Nationwide Childrens Hospital
Ramirez, Nilsa C.
United States, Columbus
Research Institute at Nationwide Childrens Hospital
Xu, Jian M.
United States, Baltimore
Johns Hopkins University
Salvesen, Helga Birgitte
Norway, Bergen
Universitetet I Bergen
Vellano, Christopher P.
United States, Houston
The University of Texas Md Anderson Cancer Center
Ju, Zhenlin
United States, Houston
The University of Texas Md Anderson Cancer Center
Ryan, Michael C.
United States, Houston
The University of Texas Md Anderson Cancer Center
Verhaak, Roel G.W.
United States, Houston
The University of Texas Md Anderson Cancer Center
Yuan, Yuan
United States, Houston
The University of Texas Md Anderson Cancer Center
Ling, Shiyun
United States, Houston
The University of Texas Md Anderson Cancer Center
Mills, Gordon B.
United States, Houston
The University of Texas Md Anderson Cancer Center
Lu, Yiling
United States, Houston
The University of Texas Md Anderson Cancer Center
Akbani, Rehan
United States, Houston
The University of Texas Md Anderson Cancer Center
Liang, Han
United States, Houston
The University of Texas Md Anderson Cancer Center
Wang, Jing
United States, Houston
The University of Texas Md Anderson Cancer Center
Zhang, Wei
United States, Houston
The University of Texas Md Anderson Cancer Center
Song, Xingzhi Henry
United States, Houston
The University of Texas Md Anderson Cancer Center
Mills-Shaw, Kenna R.
United States, Houston
The University of Texas Md Anderson Cancer Center
DiSaia, Philip John
United States, Irvine
University of California, Irvine
Radenbaugh, Amie J.
United States, Santa Cruz
University of California, Santa Cruz
Haussler, David H.
United States, Santa Cruz
University of California, Santa Cruz
Fridley, Brooke L.
United States, Kansas City
University of Kansas Medical Center
Godwin, Andrew K.
United States, Kansas City
University of Kansas Medical Center
Parker, Joel S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hoadley, Katherine A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Wilkerson, Matthew D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Roach, Jeffrey M.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Huang, Mei
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Jones, Corbin D.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Zuna, Rosemary E.
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Walker, Joan L.
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Brown, David W.G.
United States, Oklahoma City
University of Oklahoma Health Sciences Center
Dhir, Rajiv J.
United States, Pittsburgh
University of Pittsburgh
Edwards, Robert P.
United States, Pittsburgh
University of Pittsburgh
Bhargava, Rohit
United States, Pittsburgh
University of Pittsburgh
Tiezzi, Daniel Guimarães
Brazil, Sao Paulo
Universidade de São Paulo
de Andrade, Jurandyr Moreira
Brazil, Sao Paulo
Universidade de São Paulo
Noushmehr, Houtan
Brazil, Sao Paulo
Universidade de São Paulo
van den Berg, David J.
United States, Los Angeles
University of Southern California
Triche, Timothy Junius
United States, Los Angeles
University of Southern California
Agnew, Kathy J.
United States, Seattle
University of Washington
Shelley, Carl Simon
United States, Madison
University of Wisconsin School of Medicine and Public Health
Laird, Peter W.
United States, Grand Rapids
Van Andel Research Institute
Statistics
Citations: 939
Authors: 130
Affiliations: 50
Identifiers
Doi:
10.1038/nature21386
ISSN:
00280836
Research Areas
Cancer
Genetics And Genomics