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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study
BMC Pregnancy and Childbirth, Volume 14, No. 1, Article 134, Year 2014
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Description
Background: Preeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia. Methods: This was a prospective cohort study involving 54 women with severe preeclampsia and eclampsia, conducted between July 2010 and February 2012 at the central maternity unit of the Yaoundé Central Hospital. Clinical and laboratory parameters were recorded from day-1 to 6 months after delivery. Mixed-linear and logistic regression models were used to relate baseline and within follow-up levels of covariates, with changes in blood pressure levels, renal function and proteinuria, as well as persisting hypertension, renal failure and proteinuria. Results: During follow-up, a significant improvement was observed in blood pressure, renal function and proteinuria (all p < 0.002). Thirteen (24.1%) patients with renal failure at delivery recovered completely within six weeks. Twenty-six (48.1%), 17 (31.5%) and 1 (1.8%) patients had persisting proteinuria at 6 weeks, 3 months and 6 months post-delivery, respectively. Corresponding figures for persisting hypertension were 23 (42.6%), 15 (27.8%) and 8 (14.8%). Advanced age, higher body mass index, low gestational age at delivery, low fetal birth weight, and proteinuria at delivery were the main risk factors for persisting hypertension at 3 months, meanwhile low fetal birth weight, severe preeclampsia and proteinuria at delivery were correlated with persisting proteinuria at 3 months. Advanced age and higher body mass index were the only determinants of the composite outcome of persisting hypertension or proteinuria at three and six months.Conclusion: Hypertension and proteinuria are very common beyond the postpartum period in Cameroonian women with severe preeclampsia and eclampsia. Long-term follow-up of these women will help preventing and controlling related complications. © 2014 Kaze et al.; licensee BioMed Central Ltd.
Authors & Co-Authors
Kaze, François Folefack
Cameroon, Yaounde
Université de Yaoundé I
Njukeng, Francis A.
Cameroon, Yaounde
Université de Yaoundé I
Kengne, Andre-Pascal Pascal
South Africa, Tygerberg
South African Medical Research Council
Ashuntantang, Gloria Enow
Cameroon, Yaounde
Université de Yaoundé I
Mbu, Robinson Enow
Cameroon, Yaounde
Université de Yaoundé I
Halle, Marie Patrice E.
Cameroon, Douala
University of Douala
Asonganyi, Tazoacha
Cameroon, Yaounde
Université de Yaoundé I
Statistics
Citations: 48
Authors: 7
Affiliations: 3
Identifiers
Doi:
10.1186/1471-2393-14-134
e-ISSN:
14712393
Research Areas
Health System And Policy
Maternal And Child Health
Noncommunicable Diseases
Sexual And Reproductive Health
Study Design
Cohort Study
Study Approach
Quantitative
Participants Gender
Female