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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Design and validation of a diagnostic score for biliary atresia
Journal of Hepatology, Volume 61, No. 1, Year 2014
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Description
Background & Aims The dilemma of early diagnosis of biliary Atresia (BA), particularly distinguishing it from other causes of neonatal cholestasis is challenging. The aim was to design and validate a scoring system for early discrimination of BA from other causes of neonatal cholestasis. Methods A twelve-point scoring system was proposed according to clinical, laboratory, ultrasonographic, and histopathological parameters. A total of 135 patients with neonatal cholestasis in two sets were recruited to design (n = 60) and validate (n = 75) a scoring system. Parameters with significant statistical difference between BA (n = 30) and non-BA (n = 30) patients in the design set were analyzed by logistic regression to predict the presence or absence of BA then a scoring system was designed and validated. Results The total score ranged from 0 to 37.18 and a cut-off value of >23.927 could discriminate BA from other causes of neonatal cholestasis with sensitivity and specificity of 100% each. By applying this score in the validation set, the accuracy was 98.83% in predicting BA. The diagnosis of BA was proposed correctly in 100% and the diagnosis of non-BA was proposed correctly in 97.67% of patients. By applying this model, unnecessary intraoperative cholangiography would be avoided in non-BA patients. Conclusions This scoring system accurately separates infants with BA and those with non-BA, rendering intraoperative cholangiography for confirming or excluding BA unnecessary in a substantial proportion of patients. © 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Authors & Co-Authors
El-Guindi, Mohamed Abdel Salam
Egypt, Shibin el Kom
Menoufia University
Sira, Mostafa Mohamed
Egypt, Shibin el Kom
Menoufia University
Sira, Ahmad Mohamed
Egypt, Shibin el Kom
Menoufia University
Salem, Tahany Abdel Hameed
Egypt, Shibin el Kom
Menoufia University
El-Abd, Osama Lotfy
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Konsowa, Hatem Abdel Sattar
Egypt, Shibin el Kom
Menoufia University
El-Azab, Dina Shehata
Egypt, Shibin el Kom
Menoufia University Faculty of Medicine
Allam, Alif Abdel Hakim
Egypt, Shibin el Kom
Menoufia University
Statistics
Citations: 92
Authors: 8
Affiliations: 2
Identifiers
Doi:
10.1016/j.jhep.2014.03.016
ISSN:
01688278
e-ISSN:
16000641
Research Areas
Maternal And Child Health