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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Overdiagnosis of COPD in Subjects With Unobstructed Spirometry: A BOLD Analysis
Chest, Volume 156, No. 2, Year 2019
Notification
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Description
Background: There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003 and 2012. Methods: A false positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but postbronchodilator spirometry was unobstructed (FEV1/FVC > LLN). Additional analyses were performed using the fixed ratio criterion (FEV1/FVC < 0.7). Results: Among 16,177 participants, 919 (5.7%) reported a previous medical diagnosis of COPD. Postbronchodilator spirometry was unobstructed in 569 subjects (61.9%): false positive COPD. A similar rate of overdiagnosis was seen when using the fixed ratio criterion (55.3%). In a subgroup analysis excluding participants who reported a diagnosis of “chronic bronchitis” or “emphysema” (n = 220), 37.7% had no airflow limitation. The site-specific prevalence of false positive COPD varied greatly, from 1.9% in low- to middle-income countries to 4.9% in high-income countries. In multivariate analysis, overdiagnosis was more common among women, and was associated with higher education; former and current smoking; the presence of wheeze, cough, and phlegm; and concomitant medical diagnosis of asthma or heart disease. Among the subjects with false positive COPD, 45.7% reported current use of respiratory medication. Excluding patients with reported asthma, 34.4% of those with normal spirometry still used a respiratory medication. Conclusions: False positive COPD is frequent. This might expose nonobstructed subjects to possible adverse effects of respiratory medication. © 2019 American College of Chest Physicians
Authors & Co-Authors
Sator, Lea
Austria, Salzburg
Paracelsus Medizinische Privatuniversitat
Horner, Andreas
Austria, Linz
Kepler Universitätsklinikum
Austria, Linz
Johannes Kepler University Linz
Austria, Salzburg
Paracelsus Medizinische Privatuniversitat
Studnicka, Michael J.
Austria, Salzburg
Paracelsus Medizinische Privatuniversitat
Lamprecht, Bernd
Austria, Linz
Kepler Universitätsklinikum
Austria, Linz
Johannes Kepler University Linz
Kaiser, Bernhard
Austria, Linz
Kepler Universitätsklinikum
McBurnie, Mary Ann
United States, Oakland
Kaiser Permanente
Buist, A. Sonia
United States, Portland
Oregon Health & Science University
Gnatiuc, Louisa
United Kingdom, London
Imperial College London
Mannino, David M.
United States, Lexington
University of Kentucky
Janson, Christer
Sweden, Uppsala
Uppsala Universitet
Bateman, Eric D.
South Africa, Cape Town
University of Cape Town
Burney, Peter G.J.
United Kingdom, London
Imperial College London
Zhong, Nanshan
Unknown Affiliation
Liu, Shengming
Unknown Affiliation
Lü, Jiachun
Unknown Affiliation
Ran, Pixin
Unknown Affiliation
Wang, Dali
Unknown Affiliation
Zheng, Jingping
Unknown Affiliation
Zhou, Yumin
Unknown Affiliation
Koçabas, Ali
Unknown Affiliation
Hancioglu, Attila
Unknown Affiliation
Hanta, İsmail
Unknown Affiliation
Kulecı, Sedat
Unknown Affiliation
Türkyılmaz, Ahmet Sinan
Unknown Affiliation
Umut, Sema
Unknown Affiliation
Ünalan, Turgay
Unknown Affiliation
Dawes, Torkil
Unknown Affiliation
Bateman, E. D.
Unknown Affiliation
Jithoo, Anamika
Unknown Affiliation
Adams, Desiree
Unknown Affiliation
Barnes, Edward
Unknown Affiliation
Freeman, Jasper
Unknown Affiliation
Hayes, Anton
Unknown Affiliation
Hlengwa, Sipho
Unknown Affiliation
Johannisen, Christine
Unknown Affiliation
Koopman, Mariana
Unknown Affiliation
Louw, Innocentia
Unknown Affiliation
Ludick, Ina
Unknown Affiliation
Olckers, Alta
Unknown Affiliation
Ryck, Johanna
Unknown Affiliation
Storbeck, Janita
Unknown Affiliation
Gíslason, Thórarinn
Unknown Affiliation
Benedikdtsdottir, Bryndis
Unknown Affiliation
Jörundsdóttir, Kristín Bára
Unknown Affiliation
Gudmundsdottir, Lovisa
Unknown Affiliation
Gudmundsdóttir, Sigrun
Unknown Affiliation
Gundmundsson, Gunnar
Unknown Affiliation
Niżankowska-Mogilnicka, Ewa
Unknown Affiliation
Frey, Jakub
Unknown Affiliation
Harat, Rafał
Unknown Affiliation
Mejza, Filip
Unknown Affiliation
Nastałek, Paweł
Unknown Affiliation
Paj̧ak, Andrzej
Unknown Affiliation
Skucha, Wojciech
Unknown Affiliation
Szczeklik, Andrzej J.
Unknown Affiliation
Twardowska, Magdalena
Unknown Affiliation
Welte, Tobias
Unknown Affiliation
Bodemann, Isabelle
Unknown Affiliation
Geldmacher, Henning
Unknown Affiliation
Schweda-Linow, Alexandra
Unknown Affiliation
Gulsvik, Around
Unknown Affiliation
Endresen, Tina
Unknown Affiliation
Svendsen, Lene Løvendahl
Unknown Affiliation
Tan, Wan Cheng
Unknown Affiliation
Cain, John
Unknown Affiliation
Copeland, Rebecca
Unknown Affiliation
Hazen, Dana
Unknown Affiliation
Methvin, Jennifer N.
Unknown Affiliation
Dantes, Renato B.
Unknown Affiliation
Amarillo, Lourdes E.
Unknown Affiliation
Berratio, Lakan U.
Unknown Affiliation
Fernandez, Lenora C.
Unknown Affiliation
Francisco, Norberto A.
Unknown Affiliation
Garcia, Gerard S.
Unknown Affiliation
de Guia, Teresita S.
Unknown Affiliation
Idolor, Luisito F.
Unknown Affiliation
Naval, Sullian S.
Unknown Affiliation
Reyes, Thessa
Unknown Affiliation
Roa, Camilo Cala
Unknown Affiliation
Sanchez, Ma Flordeliza
Unknown Affiliation
Simpao, Leander P.
Unknown Affiliation
Jenkins, Christine R.
Unknown Affiliation
Marks, Guy B.
Unknown Affiliation
Bird, Tessa E.
Unknown Affiliation
Espinel, Paola
Unknown Affiliation
Hardaker, Kate M.
Unknown Affiliation
Toelle, Brett G.
Unknown Affiliation
Burney, Peter G.J.
Unknown Affiliation
Amor, Caron
Unknown Affiliation
Potts, James F.
Unknown Affiliation
Tumilty, Michael K.
Unknown Affiliation
McLean, Fiona
Unknown Affiliation
Wouters, Emiel F.M.
Unknown Affiliation
Wesseling, Geertjan
Unknown Affiliation
Bárbara, Cristina
Unknown Affiliation
Rodrigues, Fátima
Unknown Affiliation
Dias, Hermínia
Unknown Affiliation
Cardoso, João V.
Unknown Affiliation
Almeida, João M.
Unknown Affiliation
Matos, Maria João
Unknown Affiliation
Simão, Paula
Unknown Affiliation
Santos, Moutinho L.
Unknown Affiliation
Ferreira, Reis
Unknown Affiliation
Jôgi, Rain
Unknown Affiliation
Laja, Hendrik
Unknown Affiliation
Ulst, Katrin
Unknown Affiliation
Zobel, Vappu
Unknown Affiliation
Lill, Toomas Julius
Unknown Affiliation
Koul, Parvaiz A.
Unknown Affiliation
Harrabi, Imed
Unknown Affiliation
Denguezli, Meriam
Unknown Affiliation
Tabka, Zouhaïr
Unknown Affiliation
Daldoul, Hager
Unknown Affiliation
Chouikha, Firas
Unknown Affiliation
Balanag, Vincent M.
Unknown Affiliation
Juvekar, Sanjay Kamlakar
Unknown Affiliation
Sambhudas, S.
Unknown Affiliation
Salvi, Sundeep Santosh
Unknown Affiliation
Madas, Sapna Jitendra
Unknown Affiliation
Obaseki, Daniel Osagbemworhue
Unknown Affiliation
Erhabor, Gregory Efosa
Unknown Affiliation
Awopeju, Olayemi Fehintola
Unknown Affiliation
Adewole, Olufemi Olanisun
Unknown Affiliation
Statistics
Citations: 61
Authors: 123
Affiliations: 9
Identifiers
Doi:
10.1016/j.chest.2019.01.015
ISSN:
00123692
Research Areas
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Participants Gender
Female