Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prevalence of antiphospholipid antibodies, factor V G1691A (Leiden) and prothrombin G20210A mutations in early and late recurrent pregnancy loss
European Journal of Obstetrics and Gynecology and Reproductive Biology, Volume 119, No. 2, Year 2005
Notification
URL copied to clipboard!
Description
Objective: We assessed the prevalence of inherited (FV-Leiden and PRT G20210A), and acquired (anti-PL antibodies) risk factors among habitual aborters in Tunisia. Study design: We studied prospectively 146 patients with ≥3 consecutive early, late, or early-late recurrent pregnancy losses, together with 99 age-matched controls. Anticardiolipin antibodies (ACL), lupus anticoagulant (LA), and APC resistance (APCR) were detected by ELISA, dilute Russell Viper Venom Time (dRVVT), and coagulation tests, respectively, and FV-Leiden and PRT G20210A genotypes were assessed by PCR. Results: Anti-PL antibody frequencies were 45 and 9% among patients and controls, respectively (P < 0.001), with positive LA only (P = 0.004), or combined elevated ACL-positive LA being consistently higher (P < 0.001) among patients than controls. FV-Leiden (20.54% versus 6.06%), but not PRT G20210A (2.74% versus 4.04%) was significantly higher in patients versus controls. Among LA-positive cases higher prevalence of G/A (14/146 versus 1/99) and A/A genotypes (4/146 versus 0/99) were seen, and among ACL-positive cases higher prevalence of G/A (10/146 versus 0/99) and A/A genotypes (2/146 versus 0/99) were recorded. Conclusions: Anti-PL antibodies and FV-Leiden, but not PRT G20210A, are associated with recurrent idiopathic pregnancy losses in Tunisian women. © 2004 Elsevier Ireland Ltd. All rights reserved.
Authors & Co-Authors
Mtiraoui, Nabil
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Borgi, Lobna
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Hizem, Sondes
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Nsiri, Brahim
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Finan, Ramzi R.
Lebanon, Beirut
Université Saint-joseph de Beyrouth
Gris, Jean Christophe R.
France, Montpellier
Université de Montpellier
Almawi, Wassim Y.
Bahrain, Manama
Arabian Gulf University
Mahjoub, Touhami
Tunisia, Monastir
Faculté de Pharmacie de Monastir
Statistics
Citations: 43
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1016/j.ejogrb.2004.07.003
ISSN:
03012115
Research Areas
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cross Sectional Study
Study Locations
Tunisia
Participants Gender
Female