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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Prospective association between the dietary inflammatory index and metabolic syndrome: Findings from the SU.VI.MAX study
Nutrition, Metabolism and Cardiovascular Diseases, Volume 25, No. 11, Year 2015
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Description
Background and aims: The prevention of the metabolic syndrome (MetS) is of major concern and nutrition has been shown to modulate at least partly MetS risk. Our objective was to investigate whether a pro-inflammatory diet was associated with a higher risk of MetS and its components in a large cohort of French adults. Methods and results: A total of 3726 participants from the Supplémentation en Vitamines et Minéraux AntioXydants (SU.VI.MAX) cohort were included in this study. The MetS status was identified at baseline and after 13 years of follow-up using self-reported medication, data from clinical investigations and biological measurements. The dietary inflammatory index (DII) was computed using repeated 24 h-dietary records (n = 10.1 ± 3.1). Logistic and linear regression analyses were conducted to assess the prospective association of the DII (as Q, quartiles) with the incidence of MetS and with the traits contributing to the MetS-definition (blood pressure, glycaemia, triglycerides, HDL-cholesterol, waist circumference).A diet with pro-inflammatory properties, as expressed by higher DII scores, was significantly associated with a higher risk of developing the MetS (OR comparing Q4 to Q1: 1.39, 95% confidence interval 1.01-1.92, P = 0.047). Moreover, higher DII scores were associated with higher systolic and diastolic blood pressure (Ptrend across quartiles = 0.03 and 0.05, respectively) and triglycerides (Ptrend = 0.01), and with lower HDL-cholesterol (Ptrend = 0.03). Conclusion: A higher DII score was prospectively associated with a higher risk of MetS, with associations with blood pressure, triglycerides and HDL-cholesterol. Promotion of a healthy diet exhibiting anti-inflammatory properties may contribute to prevent cardio-metabolic disorders. © 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.
Authors & Co-Authors
Fézeu, Léopold K.
France, Paris
Centre de Recherche Epidémiologiques et Bio Statistiques de Sorbonne Paris Cité Cress
Touvier, Mathilde
France, Paris
Centre de Recherche Epidémiologiques et Bio Statistiques de Sorbonne Paris Cité Cress
Shivappa, Nitin
United States, Columbia
University of South Carolina
United States, Columbia
Connecting Health Innovations Llc
Hébert, James R.
United States, Columbia
University of South Carolina
United States, Columbia
Connecting Health Innovations Llc
Wirth, Michael D.
United States, Columbia
University of South Carolina
United States, Columbia
Connecting Health Innovations Llc
Hercberg, Serge
France, Paris
Centre de Recherche Epidémiologiques et Bio Statistiques de Sorbonne Paris Cité Cress
France, Bobigny
Hopital Avicenne
Galán, Pilar Redondo
France, Paris
Centre de Recherche Epidémiologiques et Bio Statistiques de Sorbonne Paris Cité Cress
Julia, Chantal
France, Paris
Centre de Recherche Epidémiologiques et Bio Statistiques de Sorbonne Paris Cité Cress
France, Bobigny
Hopital Avicenne
Kesse-Guyot, Emmanuelle
France, Paris
Centre de Recherche Epidémiologiques et Bio Statistiques de Sorbonne Paris Cité Cress
Statistics
Citations: 106
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1016/j.numecd.2015.09.002
ISSN:
09394753
Research Areas
Food Security
Health System And Policy
Noncommunicable Diseases
Study Design
Cohort Study