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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Species distinction in the Trichophyton rubrum complex
Journal of Clinical Microbiology, Volume 57, No. 9, Article e00352-19, Year 2019
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Description
The Trichophyton rubrum species complex comprises commonly encountered dermatophytic fungi with a worldwide distribution. The members of the complex usually have distinct phenotypes in culture and cause different clinical symptoms, despite high genome similarity. In order to better delimit the species within the complex, molecular, phenotypic, and physiological characteristics were combined to reestablish a natural species concept. Three groups, T. rubrum, T. soudanense, and T. violaceum, could be distinguished based on the sequence of the internal transcribed spacer (ITS) ribosomal DNA barcode gene. On average, strains within each group were similar by colony appearance, microscopy, and physiology, but strains between groups showed significant differences. Trichophyton rubrum strains had higher keratinase activity, whereas T. violaceum strains tended to be more lipophilic; however, none of the phenotypic features were diagnostic. The results of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and amplified fragment length polymorphism (AFLP) were partially consistent with the ITS data but failed to distinguish the species unambiguously. Despite their close similarity, T. violaceum, T. soudanense, and T. rubrum can be regarded as independent species with distinct geographical distributions and clinical predilections. Trichophyton soudanense is pheno- and genotypically intermediate between T. rubrum and T. violaceum. For routine diagnostics, ITS sequencing is recommended. Copyright © 2019 American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6711931/bin/JCM.00352-19-s0001.pdf
https://efashare.b-cdn.net/share/pmc/articles/PMC6711931/bin/JCM.00352-19-s0002.xlsx
https://efashare.b-cdn.net/share/pmc/articles/PMC6711931/bin/JCM.00352-19-s0003.xlsx
Authors & Co-Authors
Ahmed, Sarah A.
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Al-Hatmi, Abdullah M.S.
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Oman, Muscat
Ministry of Health Oman
İLki̇t, Macit It
Turkey, Adana
Çukurova Üniversitesi
Hagen, Ferry
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Netherlands, Utrecht
University Medical Center Utrecht
Gráser, Yvonne
Germany, Berlin
Charité – Universitätsmedizin Berlin
Deng, Shuwen
Unknown Affiliation
Hendrickx, Marijke
Belgium, Brussels
Sciensano
Xu, Jinhua
China, Shanghai
Fudan University
de Hoog, Gerrits Sybren
Netherlands, Nijmegen
Canisius Wilhelmina Ziekenhuis
Netherlands, Utrecht
Westerdijk Fungal Biodiversity Institute - Knaw
Statistics
Citations: 36
Authors: 9
Affiliations: 8
Identifiers
Doi:
10.1128/JCM.00352-19
ISSN:
00951137
Research Areas
Genetics And Genomics