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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
HIV-specific IgA antibodies in tears of children with aids or at risk of AIDS
Research in Virology, Volume 141, No. 3, Year 1990
Notification
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Description
To improve on the diagnosis of human immunodeficiency virus (HIV) infection, 14 children with clinical evidence of AIDS, 86 children less than 15 months old and born to seropositive mothers, and 29 controls were tested for the presence of IgA antibody in tears directed against HIV antigens on Western blots. IgA antibodies in tears against env- and pol-encoded proteins were present in 13 of 14 children with AIDS and in 13 of 86 children born to seropositive mothers. No HIV-specific IgA was observed in tears of the 29 controls. Among the 86 children less than 15 months old, 11 had clinical evidence of AIDS and 7 of them (64%) had HIV-specific IgA in tears. Results show that the demonstration of lacrimal HIV-specific IgA may help to distinguish between truly infected children and those whose HIV antibodies are passively transferred from the mother. Therefore, this simple method is a good tool for laboratory diagnosis of paediatric AIDS. © 1990.
Authors & Co-Authors
Renom, G.
Central African Republic, Bangui
Institut Pasteur de Bangui
Bouquety, J. C.
Unknown Affiliation
Lanckriet, C.
Unknown Affiliation
Georges, Alain Jean
Central African Republic, Bangui
Institut Pasteur de Bangui
Siopathis, M. R.
Unknown Affiliation
Martin, Paul M.V.
Central African Republic, Bangui
Institut Pasteur de Bangui
Statistics
Citations: 15
Authors: 6
Affiliations: 2
Identifiers
Doi:
10.1016/0923-2516(90)90007-6
ISSN:
09232516
Research Areas
Infectious Diseases
Maternal And Child Health