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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Efficacy and safety of human menopausal gonadotrophins versus recombinant FSH: A meta-analysis
Reproductive BioMedicine Online, Volume 16, No. 1, Year 2008
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Description
LH activity has been proposed to influence treatment response and outcome. In order to assess its clinical profile and efficacy, human menopausal gonadotrophin (FIMG) was compared with recombinant FSH (r-FSH) in IVF/intracytoplasmic sperm injection (ICSI) cycles. Computerized and hand searches were conducted for relevant citations. Primary outcome measures were live-birth and OHSS rates. Secondary outcomes were clinical pregnancy, multiple pregnancy, miscarriage rates and cycle characteristics. The live-birth rate was significantly higher with HMG [odds ratio (OR) = 1.20, 95% CI = 1.01-1.42] versus r-FSH, but OHSS rates (OR = 1.21, 95% CI = 0.78-1.86) were not significantly different. As for the secondary outcomes, there was statistical significance with regard to the clinical pregnancy rate also in favour of the HMG group. Even so, there were significantly fewer treatment days, total dose and embryos produced in the r-FSH group compared with the HMG group. The other secondary outcomes were not different between the two groups. In conclusion, HMG has been demonstrated to be superior to r-FSH with regard to the clinical outcomes, with equivalent patient safety during assisted reproduction. © 2008 Published by Reproductive Healthcare Ltd.
Authors & Co-Authors
Al-Inany, Hesham Gaber
Egypt, Cairo
The Egyptian Ivf-et Centre
Egypt, Cairo
Faculty of Medicine
Abou-Setta, Ahmed M.
Egypt, Cairo
Faculty of Medicine
Aboulghar, Mohamed A.
Egypt, Cairo
The Egyptian Ivf-et Centre
Egypt, Cairo
Faculty of Medicine
Mansour, Ragaa T.
Egypt, Cairo
The Egyptian Ivf-et Centre
Serour, Gamal I.
Egypt, Cairo
The Egyptian Ivf-et Centre
Statistics
Citations: 90
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/S1472-6483(10)60559-7
ISSN:
14726483
Research Areas
Health System And Policy
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Case-Control Study
Study Approach
Systematic review