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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Elevated risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variants compared with Alpha variant in vaccinated individuals
Science Translational Medicine, Volume 15, No. 684, Article abn4338, Year 2023
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Description
The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) break through infection- or vaccine-induced immunity is not well understood. We analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We found evidence of an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared with the Alpha (B.1.1.7) variant after vaccination. No clear differences were found between vaccines. However, the effect was larger in the first 14 to 59 days after complete vaccination compared with ≥60 days. In contrast to vaccine-induced immunity, there was no increased risk for reinfection with Beta, Gamma, or Delta variants relative to the Alpha variant in individuals with infection-induced immunity. © 2023 American Association for the Advancement of Science. All rights reserved.
Authors & Co-Authors
Vennema, Harry
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Veldhuijzen, Irene Karen
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Hahné, Susan J.M.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Reusken, Chantal B.E.M.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Knol, Mirjam J.
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Eggink, Dirk
Netherlands, Bilthoven
Rijksinstituut Voor Volksgezondheid en Milieu
Jonges, Marcel
Netherlands, Amsterdam
Amsterdam Umc - University of Amsterdam
Molenkamp, Richard
Netherlands, Rotterdam
Erasmus Mc
Nieuwenhuijse, David F.
Netherlands, Rotterdam
Erasmus Mc
Sikkema, Reina S.
Netherlands, Rotterdam
Erasmus Mc
Oude-Munnink, Bas B.
Netherlands, Rotterdam
Erasmus Mc
Koopmans, Marion P.G.
Netherlands, Rotterdam
Erasmus Mc
van der Zanden, Adri G.M.
Netherlands, Hengelo
Laboratory for Medical Microbiology and Public Health
Smit, Pieter Willem
Netherlands, Rotterdam
Maasstad Ziekenhuis
Pas, Suzan D.
Unknown Affiliation
Verweij, Jaco J.
Unknown Affiliation
Dingemans, Jozef
Netherlands, Maastricht
Universiteit Maastricht
Wensing, Annemarie Marie J.
Netherlands, Utrecht
University Medical Center Utrecht
Hofstra, Laura Marije
Netherlands, Utrecht
University Medical Center Utrecht
Coolen, Jordy P.M.
Netherlands, Nijmegen
Radboud University Medical Center
Melchers, Willem J.G.
Netherlands, Nijmegen
Radboud University Medical Center
Wertheim, Heiman Frank Louis
Netherlands, Nijmegen
Radboud University Medical Center
Dijkman, Remco
Netherlands, Nijmegen
Radboud University Medical Center
Koppelman, Marco H.G.M.
Netherlands, Amsterdam
Stichting Sanquin Bloedvoorziening
van Benthem, Birgit H.B.
Unknown Affiliation
van den Brink, Sharon V.D.
Unknown Affiliation
Geubbels, Eveline
Unknown Affiliation
van den Hof, Susan
Unknown Affiliation
Jaarsma, Ryanne Isolde
Unknown Affiliation
van de Kassteele, Jan
Unknown Affiliation
Kroneman, A.
Unknown Affiliation
Schipper, Maarten
Unknown Affiliation
Wijburg, Sara R.
Unknown Affiliation
Wijsman, Lisa A.
Unknown Affiliation
Statistics
Citations: 18
Authors: 34
Affiliations: 11
Identifiers
Doi:
10.1126/scitranslmed.abn4338
ISSN:
19466234
Research Areas
Covid