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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe
PLoS ONE, Volume 8, No. 6, Article e65960, Year 2013
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Description
Background:Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have mostly been conducted using the bite of infected mosquitoes, restricting the number of trial sites that can perform CHMI studies. Aseptic, cryopreserved P. falciparum sporozoites (PfSPZ Challenge) provide a potentially more accurate, reproducible and practical alternative, allowing a known number of sporozoites to be administered simply by injection.Methodology:We sought to assess the infectivity of PfSPZ Challenge administered in different dosing regimens to malaria-naive healthy adults (n = 18). Six participants received 2,500 sporozoites intradermally (ID), six received 2,500 sporozoites intramuscularly (IM) and six received 25,000 sporozoites IM.Findings:Five out of six participants receiving 2,500 sporozoites ID, 3/6 participants receiving 2,500 sporozoites IM and 6/6 participants receiving 25,000 sporozoites IM were successfully infected. The median time to diagnosis was 13.2, 17.8 and 12.7 days for 2,500 sporozoites ID, 2,500 sporozoites IM and 25,000 sporozoites IM respectively (Kaplan Meier method; p = 0.024 log rank test).Conclusions:2,500 sporozoites ID and 25,000 sporozoites IM have similar infectivities. Given the dose response in infectivity seen with IM administration, further work should evaluate increasing doses of PfSPZ Challenge IM to identify a dosing regimen that reliably infects 100% of participants.Trial Registration:ClinicalTrials.gov NCT01465048. © 2013 Sheehy et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s001.tif
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https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s004.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s005.docx
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https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s007.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s008.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s009.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s010.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s011.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3688861/bin/pone.0065960.s012.pdf
Authors & Co-Authors
Sheehy, Susanne Helena
United Kingdom, Oxford
University of Oxford
Spencer, Alexandra J.
United Kingdom, Oxford
University of Oxford
Douglas, Alexander D.
United Kingdom, Oxford
University of Oxford
Sim, Betty Kim Lee
United States, Rockville
Sanaria Inc.
Longley, Rhea J.
United Kingdom, Oxford
University of Oxford
Edwards, Nick J.
United Kingdom, Oxford
University of Oxford
Poulton, Ian D.
United Kingdom, Oxford
University of Oxford
Kimani, Domtila
Kenya, Nairobi
Kenya Medical Research Institute
Williams, Andrew R.
United Kingdom, Oxford
University of Oxford
Anagnostou, Nicholas A.
United Kingdom, Oxford
University of Oxford
Roberts, Rachel
United Kingdom, Oxford
University of Oxford
Kerridge, Simon A.
United Kingdom, Oxford
University of Oxford
Voysey, Merryn
United Kingdom, Oxford
University of Oxford Medical Sciences Division
James, Eric Robinson
United States, Rockville
Sanaria Inc.
Billingsley, Peter F.
United States, Rockville
Sanaria Inc.
Gunasekera, Anusha Munasinghe
United States, Rockville
Sanaria Inc.
Lawrie, Alison M.
United Kingdom, Oxford
University of Oxford
Hoffman, Stephen L.
United States, Rockville
Sanaria Inc.
Hill, Adrian V. S.
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 84
Authors: 19
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0065960
e-ISSN:
19326203
Research Areas
Infectious Diseases