Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Invasive nontyphoidal salmonella infections among children in Mali, 2002-2014: Microbiological and epidemiologic features guide vaccine development
Clinical Infectious Diseases, Volume 61, Year 2015
Notification
URL copied to clipboard!
Description
Background. In 2002, following establishment of a clinical microbiology laboratory in the government hospital that admits children with severe illnesses in Bamako, Mali, surveillance to identify pathogens causing invasive bacterial infections (septicemia, bacteremia, meningitis, etc) was initiated. Methods. Parents/guardians of children aged <16 years admitted to l'Hôpital Gabriel Touré with high fever or clinical syndromes compatible with focal invasive bacterial disease were asked for consent to culture their child's blood/body fluid. Standard bacteriologic techniques speciated isolates; Salmonella serovars were determined. Results. From July 2002 through June 2014, 687 nontyphoidal Salmonella (NTS) isolates were obtained from 667 children; 667 yielded a single serovar and 20 grew 2 Salmonella serovars, 1 being NTS. Four serovars accounted for 87% of the 687 NTS isolates, including Salmonella Enteritidis (n = 244 [35.5%]), Salmonella Typhimurium (n = 221 [32.2%]), I:4,[5],12:i:- (n = 42 [6.1%]), and Salmonella Dublin (n = 89 [13.0%]). Of 553 patients with invasive NTS from whom 1 of the 4 predominant serovars was isolated in pure culture, 448 (81.0%) were aged <5 years and case fatality was 20.3%; Salmonella Enteritidis case fatality (27.8%) was higher than for other serovars (P =. 0009). NTS disease showed a seasonal peak following the rainy season and into the cool, dry season. Since 2010, Salmonella Enteritidis cases have risen and Salmonella Typhimurium fallen. Conclusions. NTS has become the predominant invasive pathogen as Haemophilus influenzae type b and pneumococcal vaccine use in Mali has diminished invasive disease due to those pathogens. The age distribution and limited serovars involved make control of NTS disease by vaccines epidemiologically feasible, if products under development prove safe and efficacious. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.
Authors & Co-Authors
Tapia, Milagritos D.
United States, Baltimore
University of Maryland, Baltimore Umb
Tennant, Sharon M.
United States, Baltimore
University of Maryland, Baltimore Umb
Bornstein, Kristin
United States, Baltimore
University of Maryland, Baltimore Umb
Onwuchekwa, Uma U.
Unknown Affiliation
Tamboura, Boubou
Unknown Affiliation
Maïga, Almoustapha Issiaka
Unknown Affiliation
Sylla, Mamadou B.
Unknown Affiliation
Sissoko, Seydou
Unknown Affiliation
Kourouma, Nana
Unknown Affiliation
Touré, Aliou Y.
Unknown Affiliation
Malle, Dramane
Unknown Affiliation
Livio, Sofie
United States, Baltimore
University of Maryland, Baltimore Umb
Sow, Samba Ousmane
Unknown Affiliation
Levin, Myron J.
United States, Baltimore
University of Maryland, Baltimore Umb
Statistics
Citations: 45
Authors: 14
Affiliations: 1
Identifiers
Doi:
10.1093/cid/civ729
ISSN:
10584838
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Mali