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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The relationship between delusions and depression in Alzheimer's disease
International Journal of Geriatric Psychiatry, Volume 17, No. 6, Year 2002
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Description
Objectives: The aim of this investigation was to study the relationship between delusions and depression in Alzheimer's disease (AD). Design: This was a cross-sectional, case control study. Setting: Neuropsychiatry Service, the Johns Hopkins School of Medicine, USA. Participants: 303 community-residing patients with probable AD according to NINCDS/ADRDA criteria were included in the study. Seventy-five patients with delusions only were compared to a control group of 228 patients who had neither delusions nor hallucinations. Patients with only hallucinations or both delusions and hallucinations were excluded. Measures: Patients were assessed clinically for the presence of delusions using the DSM-IV glossary definitions. They were also rated on standardized measures of depression, cognitive impairment, staging of dementia, general medical health, and functional impairment. Results: There was an association between delusions and depression among patients with AD. Before adjustment for other variables, the presence of depression conferred a 1.8-fold (95% confidence intervals (CI) = 1.0-3.1; p = 0.04) higher risk of delusions. After adjustment for multiple other variables, this risk increased further to 6.8-fold (95% CI = 2.1-21.6; p = 0.001). Conclusions: Delusions in AD are strongly associated with depression after statistical adjustment for all confounding variables, which might distort this association. This finding has implications for our understanding of the etio-pathogenesis and management of delusions and depression in AD. Copyright © 2002 John Wiley & Sons, Ltd.
Authors & Co-Authors
Bassiony, Medhat Mohamed
Egypt, Zagazig
Zagazig University, Faculty of Medicine
Warren, Andrew
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Copper Ridge Institute
Rosenblatt, Adam
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Copper Ridge Institute
Baker, Alva
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Copper Ridge Institute
Steinberg, Martin
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Copper Ridge Institute
Steele, Cynthia D.
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Copper Ridge Institute
Sheppard, Jeanie Marie E.
United States, Baltimore
Johns Hopkins University
Lyketsos, Constantine George
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Copper Ridge Institute
United States, Baltimore
The Johns Hopkins Hospital
Statistics
Citations: 39
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1002/gps.641
Research Areas
Health System And Policy
Mental Health
Study Design
Randomised Control Trial
Cross Sectional Study
Case-Control Study