Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mortality in the catastrophic antiphospholipid syndrome: Causes of death and prognostic factors in a series of 250 patients
Arthritis and Rheumatism, Volume 54, No. 8, Year 2006
Notification
URL copied to clipboard!
Description
Objective. To assess the main causes of death and the prognostic factors that influence mortality in patients with the catastrophic antiphospholipid syndrome (CAPS). Methods. We analyzed the case reports of 250 patients included in the CAPS Registry up to February 2005. To identify prognostic factors for CAPS, we compared the main clinical and immunologic features and the types of treatment in the patients who died with those features in the patients who survived. Results. Recovery occurred in 56% of the episodes of CAPS and death occurred in 44%. Cerebral involvement, consisting mainly of stroke, cerebral hemorrhage, and encephalopathy, was considered the main cause of death, being present in 27.2% of patients, followed by cardiac involvement (19.8%) and infection (19.8%). The only factor we identified that was prognostic of a higher mortality rate was the presence of systemic lupus erythematosus (SLE). A higher recovery rate was associated with combined treatment with anticoagulants (ACs) plus corticosteroids (CS) plus plasma exchange (PE) (77.8%), followed by ACs plus CS plus PE and/or intravenous immunoglobulins (69%). In contrast, concomitant treatment with cyclophosphamide did not demonstrate additional benefit. Conclusion. Cerebral involvement (mainly consisting of stroke), cardiac involvement, and infections were considered the main causes of death in patients with CAPS. The presence of SLE was related to a higher mortality rate. According to the results of the present study, ACs plus CS plus PE should be the first line of therapy in patients with CAPS. © 2006, American College of Rheumatology.
Authors & Co-Authors
Bucciarelli, Silvia
Spain, Barcelona
Hospital Clinic Barcelona
Espinosa, Gerard
Spain, Barcelona
Hospital Clinic Barcelona
Cervera, Ricard
Spain, Barcelona
Hospital Clinic Barcelona
Erkan, Doruk
United States, New York
Weill Cornell Medicine
Gómez-Puerta, José A.
Spain, Barcelona
Hospital Clinic Barcelona
Ramos-Casals, Manuel
Spain, Barcelona
Hospital Clinic Barcelona
Font, Josep Maria
Spain, Barcelona
Hospital Clinic Barcelona
Asherson, Ronald A.
South Africa, Johannesburg
University of the Witwatersrand
Statistics
Citations: 311
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1002/art.22018
ISSN:
00043591
Research Areas
Noncommunicable Diseases