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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
IFITM3 and susceptibility to respiratory viral infections in the community
Journal of Infectious Diseases, Volume 209, No. 7, Year 2014
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Description
Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM 1,2, and 3) are viral restriction factors that mediate cellular resistance to several viruses. We have genotyped a possible splice-site altering single-nucleotide polymorphism (rs12252) in the IFITM3 gene in 34 patients with H1N1 influenza and severe pneumonia, and >5000 individuals comprising patients with community-acquired mild lower respiratory tract infection and matched controls of Caucasian ancestry. We found evidence of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptibility to severe H1N1 infection. © The Author 2013.
Authors & Co-Authors
Mills, Tara C.
United Kingdom, Oxford
University of Oxford
Rautanen, Anna
United Kingdom, Oxford
University of Oxford
Parks, Tom
United Kingdom, Oxford
University of Oxford
Naranbhai, Vivek
United Kingdom, Oxford
University of Oxford
Ieven, Margareta M.
Belgium, Edegem
Universitair Ziekenhuis Antwerpen
Butler, Christopher C.
United Kingdom, Cardiff
Cardiff University
Little, Paul S.
United Kingdom, Southampton
University of Southampton
Goossens, Herman J.
Belgium, Antwerpen
Universiteit Antwerpen
Chapman, Stephen James
United Kingdom, Oxford
University of Oxford
Hill, Adrian V. S.
United Kingdom, Oxford
University of Oxford
Statistics
Citations: 59
Authors: 10
Affiliations: 8
Identifiers
Doi:
10.1093/infdis/jit468
ISSN:
00221899
Research Areas
Genetics And Genomics