Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
First molecular epidemiology study of Mycobacterium tuberculosis in Burkina Faso
Journal of Clinical Microbiology, Volume 45, No. 3, Year 2007
Notification
URL copied to clipboard!
Description
We conducted a molecular epidemiology study on 120 Mycobacterium tuberculosis isolates from patients presenting pulmonary tuberculosis (TB) in Burkina Faso. Classical antibiogram studies and genetic characterization, using mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) typing and spoligotyping, were applied after culture. Molecular analysis of specific signatures showed that all TB cases reported in this study were caused by M. tuberculosis and identified no Mycobacterium bovis or Mycobacterium africanum isolates. This result is unexpected, as M. africanum strains were reportedly the etiologic agent in 20% of TB cases 2 decades ago. The comparison of spoligotypes from Burkina Faso with an international spoligotype database (SpolDB4) showed that the majority of isolates belong to major clades of M. tuberculosis (Haarlem, 9%; Latin American-Mediterranean, 30%; and T, 20%). The predominant group of isolates (30%) corresponds to spoligotype 61, described in Cameroon as the "Cameroon family." In Burkina Faso, as in Cameroon, this family could be associated with recent transmission of TB, suggesting a recent expansion in West Africa. Our data suggest a low level of primary drug resistance that may be a positive result of the Directly Observed Therapy Shortcourse program. Besides, based on spoligotyping plus MIRU-VNTR, data showed a high number of clusters in our sample, suggesting a high level of recent TB transmission in Burkina Faso. Nevertheless, an important genetic polymorphism was observed in this country, reflecting an endemicity situation where the control of TB would have less impact in the main towns. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Godreuil, Sylvain
France, Montpellier
Hopital Arnaud de Villeneuve
France, Paris
Cnrs Centre National de la Recherche Scientifique
Torrea, Gabriela
Burkina Faso, Ouagadougou
Centre Muraz
Terru, D.
France, Montpellier
Hopital Arnaud de Villeneuve
Chevenet, François
France, Paris
Cnrs Centre National de la Recherche Scientifique
Diagbouga, Serge P.
Burkina Faso, Ouagadougou
Centre Muraz
Supply, Philip
France, Lille
Institut Pasteur de Lille
van de Perre, Philippe
France, Montpellier
Hopital Arnaud de Villeneuve
Burkina Faso, Ouagadougou
Centre Muraz
Carrière, Christian
France, Montpellier
Hopital Arnaud de Villeneuve
Anne-Laure, Bañuls Laure
France, Paris
Cnrs Centre National de la Recherche Scientifique
Statistics
Citations: 85
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1128/JCM.01918-06
ISSN:
00951137
Research Areas
Genetics And Genomics
Infectious Diseases
Study Locations
Multi-countries
Burkina Faso
Cameroon