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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Tightly linked markers for the neurofibromatosis type 1 gene
Genomics, Volume 1, No. 4, Year 1987
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Description
Relationships among genetic markers in the region of the neurofibromatosis type 1 (NF1) gene on chromosome 17 were investigated by linkage studies in a large sample set of affected families and in a panel of 58 normal families. A new marker, pHHH202 (D17S33), was included along with two markers known to be closely linked to NF. The maximum likelihood estimate of the recombination rate between the pHHH202 and NF1 loci was found to be 0. Multilocus analysis suggested the following marker order: pA10-41-(p3-6, pHHH202); the NF1 gene fell with equal likelihood between either pA10-41-p3-6 or p3-6-pHHH202. The odds against NF1 being outside this cluster of tightly linked markers were >15:1. © 1987.
Authors & Co-Authors
White, Raymond L.
United States, Salt Lake City
University of Utah Health Sciences
Nakamura, Yusuke
United States, Salt Lake City
University of Utah Health Sciences
O'Connell, Peter
United States, Salt Lake City
University of Utah Health Sciences
Leppert, Mark F.
United States, Salt Lake City
University of Utah Health Sciences
Lalouel, Jean Marc
United States, Salt Lake City
University of Utah Health Sciences
Barker, David F.
United States, Salt Lake City
University of Utah Health Sciences
Goldgar, David F.
United States, Salt Lake City
University of Utah Health Sciences
Skolnick, Mark H.
United States, Salt Lake City
University of Utah Health Sciences
Carey, John
United States, Salt Lake City
University of Utah Health Sciences
Wallis, Colin E.
South Africa, Cape Town
Faculty of Health Sciences
Slater, C. P.
South Africa, Cape Town
Faculty of Health Sciences
Mathew, Christopher G.
United Kingdom, London
The Institute of Cancer Research
Ponder, Bruce A.J.
United Kingdom, London
The Institute of Cancer Research
Statistics
Citations: 37
Authors: 13
Affiliations: 3
Identifiers
Doi:
10.1016/0888-7543(87)90040-1
ISSN:
08887543
e-ISSN:
10898646
Research Areas
Genetics And Genomics