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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: Fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5
Journal of Virology, Volume 81, No. 17, Year 2007
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Description
Vitamin K-dependent coagulation factors can promote adenoviral cell transduction in vitro. In vivo, warfarin pretreatment ablates liver targeting of an adenovirus serotype 5 (Ad5) vector deleted of CAR binding capability. Here, we assess in vivo transduction and biodistribution of Ad5 vectors with nonmodified fibers (Ad5) and a serotype 47 fiber-pseudotyped Ad5 (Ad5/47; subgroup D) virus following intravascular injection. Warfarin reduced liver transduction by both viruses. However, no impact on early liver virus accumulation was observed, suggesting no effect on Kupffer cell interactions. Hence, coagulation factors play a pivotal role in selectively mediating liver hepatocyte transduction of Ad5 and Ad5/47 vectors. Copyright © 2007, American Society for Microbiology. All Rights Reserved.
Authors & Co-Authors
Waddington, Simon N.
United Kingdom, London
Ucl Medical School
Parker, Alan L.
United Kingdom, London
British Heart Foundation
Havenga, Menzo J.E.
Netherlands, Leiden
Crucell nv
Nicklin, Stuart A.
United Kingdom, London
British Heart Foundation
Buckley, Suzanne M.K.
United Kingdom, London
Ucl Medical School
McVey, John H.
United Kingdom, London
Imperial College London
Baker, Andrew H.
United Kingdom, London
British Heart Foundation
United Kingdom, Glasgow
University of Glasgow
Statistics
Citations: 82
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1128/JVI.00663-07
ISSN:
0022538X