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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The Spectrum of Cancers in West Africa: Associations with Human Immunodeficiency Virus
PLoS ONE, Volume 7, No. 10, Article e48108, Year 2012
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Description
Background: Cancer is a growing co-morbidity among HIV-infected patients worldwide. With the scale-up of antiretroviral therapy (ART) in developing countries, cancer will contribute more and more to the HIV/AIDS disease burden. Our objective was to estimate the association between HIV infection and selected types of cancers among patients hospitalized for diagnosis or treatment of cancer in West Africa. Methods: A case-referent study was conducted in referral hospitals in Côte d'Ivoire and Benin. Each participating clinical ward enrolled all adult patients seeking care for a confirmed diagnosis of cancer and clinicians systematically proposed an HIV test. HIV prevalence was compared between AIDS-defining cancers and a subset of selected non-AIDS defining cancers to a referent group of non-AIDS defining cancers not reported in the literature to be positively or inversely associated with HIV. An unconditional logistic model was used to estimate odds ratios (OR) and their 95% confidence intervals (CI) of the risk of being HIV-infected for selected cancers sites compared to a referent group of other cancers. Results: The HIV overall prevalence was 12.3% (CI 10.3-14.4) among the 1,017 cancer cases included. A total of 442 patients constituted the referent group with an HIV prevalence of 4.7% (CI 2.8-6.7). In multivariate analysis, Kaposi sarcoma (OR 62.2 [CI 22.1-175.5]), non-Hodgkin lymphoma (4.0 [CI 2.0-8.0]), cervical cancer (OR 7.9 [CI 3.8-16.7]), anogenital cancer (OR 11.6 [CI 2.9-46.3]) and liver cancer (OR 2.7 [CI 1.1-7.7]) were all associated with HIV infection. Conclusions: In a time of expanding access to ART, AIDS-defining cancers remain highly associated with HIV infection. This is to our knowledge, the first study reporting a significant association between HIV infection and liver cancer in sub-Saharan Africa. © 2012 Tanon et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3483170/bin/pone.0048108.s001.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3483170/bin/pone.0048108.s002.docx
Authors & Co-Authors
Tanon, Aristophane Koffi
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Jaquet, Antoine
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Ékouévi, Didier Koumavi
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Akakpo, Jocelyn
Benin
Cnhu
Adoubi, Innocent
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Diomandé, Isidore M.
Cote D'ivoire, Abidjan
C.h.u. de Cocody
Houngbè, Fabien
Benin
Cnhu
Zannou, Djimon Marcel
Benin
Cnhu
Sasco, Annie Jeanne
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Eholié, Serge Paul
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Dabis, Franćois Ç.Ois
France, Bordeaux
Université de Bordeaux
France, Paris
Inserm
Bissagnéné, Emmanuel
Cote D'ivoire, Abidjan
Centre Hospitalier Universitaire de Treichville
Statistics
Citations: 52
Authors: 12
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0048108
e-ISSN:
19326203
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study
Case-Control Study
Study Locations
Multi-countries
Benin
Ivory Coast