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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
chemistry
Synthesis and enzyme inhibitory activities of some new pyrazole-based heterocyclic compounds
Medicinal Chemistry Research, Volume 21, No. 10, Year 2012
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Description
Three tridentate N,N-bis(3,5-dimethylpyrazol- 1-ylmethyl)-1-hydroxy-2- aminoethane (2), N,N-bis(3,5-dimethylpyrazol- 1-ylmethyl)-cyclohexylamine (3) and 2-[bis (1,5-dimethyl-1H-pyrazol-3-ylmethyl)amino]ethan-1-ol (4) are synthesized and spectroscopically characterized togetherwith 1-hydroxymethyl-3,5-dimethylpyrazole (1). These have been tested in inhibitory activities against various hyperactive enzymes like urease, β- glucuronidase, phosphodiesterase, α-chymotrypsin, acetylcholinesterase and butyrylcholinesterase. Compounds 1, 2 and 3 were found to be selective inhibitors of urease. Compound 4 was found to be selective inhibitor of butyrylcholinesterase. The nature of the junction between pyrazoles cycles determined the activities of these tripods. While the tripods are inactive towards urease or glucuronidase, they turn to be selective towards butyrylcholinesterase. © Springer Science+Business Media, LLC 2011.
Authors & Co-Authors
Harit, T.
Morocco, Oujda
Université Mohammed Premier Oujda
Malek, Fouad
Morocco, Oujda
Université Mohammed Premier Oujda
El Bali, Brahim El L.
Morocco, Oujda
Université Mohammed Premier Oujda
Khan, Ajmal L.
Pakistan, Karachi
University of Karachi
Dalvandi, Kourosh
Pakistan, Karachi
University of Karachi
Marasini, Bishnu P.
Pakistan, Karachi
University of Karachi
Noreen, Shagufta
Pakistan, Karachi
University of Karachi
Malik, Rizwana
Pakistan, Karachi
University of Karachi
Khan, Sadia
Pakistan, Karachi
University of Karachi
Choudhary, Mohammed Iqbal
Pakistan, Karachi
University of Karachi
Saudi Arabia, Riyadh
King Saud University
Statistics
Citations: 45
Authors: 10
Affiliations: 3
Identifiers
Doi:
10.1007/s00044-011-9804-0
ISSN:
10542523