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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Differential spontaneous folding of mycolic acids from Mycobacterium tuberculosis
Chemistry and Physics of Lipids, Volume 180, Year 2014
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Description
Mycolic acids are structural components of the mycobacterial cell wall that have been implicated in the pathogenicity and drug resistance of certain mycobacterial species. They also offer potential in areas such as rapid serodiagnosis of human and animal tuberculosis. It is increasingly recognized that conformational behavior of mycolic acids is very important in understanding all aspects of their function. Atomistic molecular dynamics simulations, in vacuo, of stereochemically defined Mycobacterium tuberculosis mycolic acids show that they fold spontaneously into reproducible conformational groupings. One of the three characteristic mycolate types, the keto-mycolic acids, behaves very differently from either α-mycolic acids or methoxy-mycolic acids, suggesting a distinct biological role. However, subtle conformational behavioral differences between all the three mycolic acid types indicate that cooperative interplay of individual mycolic acids may be important in the biophysical properties of the mycobacterial cell envelope and therefore in pathogenicity. © 2013 The Authors.
Authors & Co-Authors
Groenewald, Wilma
South Africa, Pretoria
University of Pretoria
United Kingdom, Bangor
Bangor University
Baird, M. S.
United Kingdom, Bangor
Bangor University
Verschoor, Jan Adrianus
South Africa, Pretoria
University of Pretoria
Minnikin, David Ernest
United Kingdom, Birmingham
University of Birmingham
Croft, Anna K.
United Kingdom, Bangor
Bangor University
United Kingdom, Nottingham
University of Nottingham
Statistics
Citations: 24
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1016/j.chemphyslip.2013.12.004
ISSN:
00093084
e-ISSN:
18732941