Publication Details

AFRICAN RESEARCH NEXUS

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immunology and microbiology

Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

Journal of Allergy and Clinical Immunology, Volume 134, No. 6, Year 2014

Background Dedicator of cytokinesis 8 (DOCK8) deficiency is typified by recurrent infections, increased serum IgE levels, eosinophilia, and a high incidence of allergic and autoimmune manifestations. Objective We sought to determine the role of DOCK8 in the establishment and maintenance of human B-cell tolerance.

Statistics
Citations: 81
Authors: 15
Affiliations: 9
Identifiers
Doi: 10.1016/j.jaci.2014.07.042
ISSN: 00916749
e-ISSN: 10976825
Study Design
Cohort Study

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