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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Metabolic syndrome in patients with systemic lupus erythematosus from Southern Spain
Lupus, Volume 17, No. 9, Year 2008
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Description
The aim of this cross-sectional study was to establish the frequency, phenotype and characteristics of metabolic syndrome (MS), as defined by the Adult Treatment Panel III, in a cohort of patients with systemic lupus erythematosus (SLE) and its possible association with cardiovascular diseases (CVD). A total of 160 patients with SLE and 245 age, sex, educational level and ethnically matched controls were included. Association with cardiovascular risk factors, SLE features, treatment of SLE and history of CVD were assessed in patients with SLE and controls with and without MS. MS was non-significantly increased in patients with SLE (20%) compared with controls (13% P = 0.083). It was more commonly observed in patients with SLE ≤40 years old (15.8%) than in controls of the same age group (4.2% P < 0.001). The mean number of MS criteria was significantly higher among patients with SLE than in controls. The frequency of CVD was also 28-fold higher among patients with SLE (11.3%) than in controls (0.4%). SLE with MS presented higher levels of inflammatory markers than SLE without MS. In a multivariate analysis, educational level, serum triglycerides, HDL-cholesterol and C3 serum levels and hydroxychloroquine use were independently associated with MS. © 2008 SAGE Publications.
Authors & Co-Authors
Sabio, José Marío
Spain, Granada
Complejo Hospitalario Universitario de Granada
Jiménez-Jáimez, Juan
Spain, Granada
Complejo Hospitalario Universitario de Granada
Hidalgo-Tenorio, Carmen
Spain, Granada
Complejo Hospitalario Universitario de Granada
González-Gay, Miguel Ángel
Spain, Lugo
Complejo Hospitalario Xeral Calde
Statistics
Citations: 72
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1177/0961203308093554
ISSN:
09612033
Research Areas
Noncommunicable Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative