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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Measure of herpesvirus-specific ocular antibody production in patients with uveitis
Journal of Clinical Virology, Volume 58, No. 4, Year 2013
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Description
Background: The amount of specific antiviral IgG in aqueous humour (AH) provides a major contribution to the diagnosis of herpesvirus uveitis. Ocular antibody production is often evaluated by comparing levels of specific and total IgG in serum and AH. The small volume of AH is a major limit for diagnosis. Objectives: To simplify the measure of ocular antibody production, we tested the quotient of serum/AH ratios of specific and control antiviral IgG, using automated quantitative serology methods on minimal volumes of AH, in confirmed and suspected herpesvirus uveitis. Study design: Serum and AH samples from herpesvirus PCR-positive uveitis patients, and from PCR-negative cases who were highly suspected to have viral uveitis were retrospectively analysed for ocular production of specific antiviral IgG using 40. μl of AH, and quantitative Enzygnost ELISA-based methods. Cataract and Fuchs cyclitis cases were used as controls. Results: Ocular production of specific antiviral IgG was demonstrated in 32 (51.6%) of 62 herpesvirus PCR-positive uveitis cases, in none of 42 controls, and in 21 (55.2%) of 38 PCR-negative cases clinically suspected to have herpesvirus uveitis. The test had absolute specificity, and its sensitivity depended on the virus, pathology and timing of sampling. Conclusion: Ocular antibody production can be measured by simple quantitative ELISA-based methods on serum and minimal volumes of AH. This specific and sensitive test, implemented in the routine virology laboratory should help the diagnosis and specific antiviral therapy management of herpesvirus uveitis. © 2013 Elsevier B.V.
Authors & Co-Authors
Bojanova, Magdalena
France, Paris
Hopital Cochin Ap-hp
Germany, Giessen
Universitätsklinikum Gießen Und Marburg, Standort Gießen
Bodaghi, Bahram
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Sorbonne Université
Hannachi, Naila
France, Paris
Hopital Cochin Ap-hp
Tunisia, Sousse
Laboratoire de Microbiologie
Jouffroy, Thomas
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Fel, Audrey
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Le Hoang, Phuc
France, Paris
Hôpital Universitaire Pitié Salpêtrière
France, Paris
Sorbonne Université
Rozenberg, Flore
France, Paris
Hopital Cochin Ap-hp
France, Paris
Université Paris Cité
Statistics
Citations: 9
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1016/j.jcv.2013.10.013
ISSN:
13866532
e-ISSN:
18735967
Study Approach
Quantitative