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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Transmission of hepatitis C virus between parents and children
American Journal of Tropical Medicine and Hygiene, Volume 75, No. 1, Year 2006
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Description
Egyptian children with infected parents are at high risk of infection with hepatitis C (HCV). Analysis of data collected during surveys of rural communities show children whose parents had antibodies to HCV (anti-HCV) were at higher risk for having anti-HCV than children whose parents did not. The association was greater with mothers than fathers and when the parent had HCV RNA. For instance, 87 (14%) of 612 children had anti-HCV whose mothers had HCV RNA compared with 28 (7%) of 401 whose mothers only had anti-HCV and 79 (2.6%) of 3,086 whose mothers were seronegative. These associations persisted after controlling for age, parenteral exposures, and serologic status of the other parent. Sequencing isolates from 13 families with parent(s) and children having HCV RNA showed 10 of 18 had genetically similar viruses. These findings suggest Egyptian children are at high risk of being infected with HCV by their parents and identification of the transmission routes would allow for preventive measures. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Mohamed, Mostafa K.
Egypt, Cairo
Faculty of Medicine - Ain Shams University
Magder, Laurence S.
United States, Baltimore
University of Maryland School of Medicine
Abdel-Hamid, Mohamed A.
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
El-Daly, May
Egypt, Cairo
National Hepatology and Tropical Medicine Research Institute
NNH Mikhail, Nabiel N.H.
Egypt, Asyut
Assiut University
Abdel-Aziz, Fatma
Egypt
Center for Field and Applied Research
Medhat, Ahmed
Egypt, Asyut
Faculty of Medicine
Thiers, Valérie
France, Paris
Cnr Hepatites Virales b et C-u370
Strickland, George Thomas
United States, Baltimore
University of Maryland School of Medicine
Statistics
Citations: 46
Authors: 9
Affiliations: 7
Identifiers
Doi:
10.4269/ajtmh.2006.75.16
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cross Sectional Study