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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation
Vaccine, Volume 29, No. 2, Year 2010
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Description
Some vaccines show poor efficacy in tropical countries. Within a birth cohort in Uganda, we investigated factors that might influence responses to BCG and tetanus immunisation. Whole blood assay responses to crude culture filtrate proteins of Mycobacterium tuberculosis (cCFP)) and tetanus toxoid (TT) were examined among 1506 and 1433 one-year-olds, respectively. Maternal Mansonella perstans infection was associated with higher interleukin (IL)-10 responses to both immunogens but no reduction in gamma interferon (IFN-γ), IL-5 and IL-13 responses; other maternal helminth infections showed little effect. Tetanus immunisation during pregnancy was associated with higher infant responses to TT; maternal BCG scar (from past immunisation) with lower infant IL-5 and IL-13 responses to cCFP. IFN-γ, IL-5 and IL-13 to TT were reduced in HIV-exposed-uninfected infants; infant malaria and HIV were associated with lower IFN-γ, IL-5 and IL-13 responses to both immunogens. We conclude that maternal helminth infections are unlikely to explain poor vaccine efficacy in the tropics. Effects of maternal immunisation on infant responses to vaccines should be explored. Prevention of infant malaria and HIV could contribute to effectiveness of immunisation programmes. © 2010 Elsevier Ltd.
Authors & Co-Authors
Elliott, Alison M.
Unknown Affiliation
Mawa, Patrice Akusa
Unknown Affiliation
Webb, Emily L.
Unknown Affiliation
Nampijja, Margaret
Unknown Affiliation
Lyadda, Nancy
Unknown Affiliation
Bukusuba, Joseph
Unknown Affiliation
Kizza, Moses
Unknown Affiliation
Namujju, Proscovia Bazanya
Unknown Affiliation
Nabulime, Juliet
Unknown Affiliation
Ndibazza, Juliet
Unknown Affiliation
Muwanga, Moses
Unknown Affiliation
Whitworth, James Ag
Unknown Affiliation
Statistics
Citations: 81
Authors: 12
Affiliations: 6
Identifiers
Doi:
10.1016/j.vaccine.2010.10.047
ISSN:
0264410X
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Uganda