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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy
Journal of Photochemistry and Photobiology B: Biology, Volume 107, No. 1, Year 2012
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Description
The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato] zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm -2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity. © 2011 Elsevier B.V. All rights reserved.
Authors & Co-Authors
Nombona, Nolwazi
South Africa, Grahamstown
Rhodes University
Maduray, Kaminee
South Africa, Pretoria
The Council for Scientific and Industrial Research
Antunes, Edith M.
South Africa, Grahamstown
Rhodes University
Karsten, Aletta Elizabeth
South Africa, Pretoria
The Council for Scientific and Industrial Research
Nyokong, Tebello
South Africa, Grahamstown
Rhodes University
Statistics
Citations: 119
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.jphotobiol.2011.11.007
ISSN:
10111344
e-ISSN:
18732682
Research Areas
Cancer