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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
veterinary
Magnetic resonance imaging characteristics of necrotizing meningoencephalitis in pug dogs
Journal of Veterinary Internal Medicine, Volume 23, No. 3, Year 2009
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Description
Background: The magnetic resonance imaging (MRI) characteristics of necrotizing meningoencephalitis (NME) are not well documented. Objectives: To describe common MRI features of NME, to compare the MRI features to histopathologic findings, and to determine whether or not MRI lesions are predictive of survival time. Animals: Eighteen Pugs with NME. Methods: Retrospective MRI case study of Pugs identified by a search of medical records at 6 veterinary institutions. Eighteen dogs met inclusion criteria of histopathologically confirmed NME and antemortem MRI exam. MRI lesions were characterized and compared with histopathology with the kappa statistic. Survival times were compared with MRI findings by use of Mann-Whitney υ-tests and Spearman's ρ. Results: Twelve of 18 lesions were indistinctly marginated with mild parenchymal contrast enhancement. Prosencephalic (17/18) lesion distribution included the parietal (16/18), temporal (16/18), and occipital (16/18) lobes. There were cerebellar (4/18) and brainstem (3/18) lesions. Asymmetric lesions were present in both gray and white matter in all dogs. Falx cerebri shift was common (11/18), and 6 dogs had brain herniation. Leptomeningeal enhancement was present in 9/18 dogs. A moderate positive association was found between parenchymal contrast enhancement and both necrosis (k = 0.45; P = .045) and monocytic inflammation (k = 0.48; P = .025). Higher MRI lesion burden was correlated with longer time from disease onset to MRI (P = .045). MRI lesion burden did not correlate to survival time. Conclusions and Clinical Importance: Asymmetric prosencephalic grey and white matter lesions with variable contrast enhancement were consistent MRI changes in Pugs with confirmed NME. While not pathognomonic for NME, these MRI characteristics should increase confidence in a presumptive diagnosis of NME in young Pugs with acute signs of neurologic disease. © 2009 by the American College of Veterinary Internal Medicine.
Authors & Co-Authors
Young, Benjamin D.
United States, College Station
Texas A&m University
Levine, Jonathan M.
United States, College Station
Texas A&m University
Fosgate, Geoffrey T.
United States, College Station
Texas A&m University
Flegel, Thomas
Germany, Leipzig
Universität Leipzig
Matiasek, Kaspar
United Kingdom, Newmarket
Animal Health Trust
Schatzberg, Scott J.
United States, Athens
University of Georgia
Statistics
Citations: 41
Authors: 6
Affiliations: 6
Identifiers
Doi:
10.1111/j.1939-1676.2009.0306.x
ISSN:
08916640
Research Areas
Health System And Policy
Study Design
Cohort Study
Case Study
Study Approach
Qualitative