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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria
The Lancet, Volume 336, No. 8725, Year 1990
Notification
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Description
Plasma levels of tumour necrosis factor (TNF) were significantly higher in 178 Gambian children with uncomplicated malaria due to Plasmodium falciparum than in 178 children with other illnesses. 110 children with cerebral malaria were studied shortly after admission to hospital; 28 subsequently died. Compared with the children with uncomplicated malaria, mean plasma TNF levels were twice as high in cerebral malaria survivors and ten times as high in the fatal cases. Although high TNF levels were associated with high parasitaemia and with hypoglycaemia, they predicted fatal outcome in cerebral malaria independently of parasitaemia and glucose concentrations. Concentrations of interleukin-1 alpha, but not interferon gamma, were also related to the severity of malaria. We conclude that increased TNF production is a normal host response to P falciparum infection, but that excessive levels of production may predispose to cerebral malaria and a fatal outcome. © 1990.
Authors & Co-Authors
Kwiatkowski, Dominic P.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Sambou, Idrissa
Gambia, Banjul
Medical Research Council Laboratories Gambia
Twumasi, Patrick A.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Greenwood, Brian M.
Gambia, Banjul
Medical Research Council Laboratories Gambia
Hill, Adrian V.S.
United Kingdom, Oxford
Mrc Weatherall Institute of Molecular Medicine
Manogue, K. R.
United States, New York
Rockefeller University
Cerami, Anthony C.
United States, New York
Rockefeller University
Castracane, J.
United States, Boston
Endogen Corporation
Brewster, David R.
Gambia, Banjul
Royal Victoria Teaching Hospital Gambia
Statistics
Citations: 886
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1016/0140-6736(90)92827-5
ISSN:
01406736
Research Areas
Cancer
Health System And Policy
Infectious Diseases
Maternal And Child Health