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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Mycobacterium tuberculosis-specific CD8
+
T cells are functionally and phenotypically different between latent infection and active disease
European Journal of Immunology, Volume 43, No. 6, Year 2013
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Description
Protective immunity to Mycobacterium tuberculosis (Mtb) remains poorly understood and the role of Mtb-specific CD8+ T cells is controversial. Here we performed a broad phenotypic and functional characterization of Mtb-specific CD8+ T cells in 326 subjects with latent Mtb infection (LTBI) or active TB disease (TB). Mtb-specific CD8+ T cells were detected in most (60%) TB patients and few (15%) LTBI subjects but were of similar magnitude. Mtb-specific CD8+ T cells in LTBI subjects were mostly TEMRA cells (CD45RA+CCR7-), coexpressing 2B4 and CD160, and in TB patients were mostly TEM cells (CD45RA-CCR7-), expressing 2B4 but lacking PD-1 and CD160. The cytokine profile was not significantly different in both groups. Furthermore, Mtb-specific CD8+ T cells expressed low levels of perforin and granulysin but contained granzymes A and B. However, in vitro-expanded Mtb-specific CD8+ T cells expressed perforin and granulysin. Finally, Mtb-specific CD8+ T-cell responses were less frequently detected in extrapulmonary TB compared with pulmonary TB patients. Mtb-specific CD8+ T-cell proliferation was also greater in patients with extrapulmonary compared with pulmonary TB. Thus, the activity of Mtb infection and clinical presentation are associated with distinct profiles of Mtb-specific CD8+ T-cell responses. These results provide new insights in the interaction between Mtb and the host immune response. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Authors & Co-Authors
Rozot, Virginie
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Vigano, Selena
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Mazza-Stalder, Jesica
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Idrizi, Elita
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Day, Cheryl Cheryl L.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Perreau, Matthieu
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Lazor-Blanchet, Catherine
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Petruccioli, Elisa
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Hanekom, Willem Albert
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Goletti, Delia
Italy, Rome
Irccs Istituto Nazionale Malattie Infettive Lazzaro Spallanzani
Bart, Pierre Alexandre
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Nicod, Laurent Pierre
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Pantaleo, Giuseppe P.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Swiss Vaccine Research Institute
Harari, Alexandre
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Switzerland, Lausanne
Swiss Vaccine Research Institute
Statistics
Citations: 172
Authors: 14
Affiliations: 4
Identifiers
Doi:
10.1002/eji.201243262
e-ISSN:
15214141
Research Areas
Infectious Diseases