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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
An assessment of the effectiveness of the measles immunization programme in Lagos, Nigeria
Annals of Tropical Medicine and Parasitology, Volume 75, No. 1, Year 1981
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Description
Sera from 224 children (mean age 10·2 months) were tested for the presence of measles haemagglutinating antibodies prior to measles vaccination. Six to eight weeks later, they were re-tested. The sera conversion rate was 53·5%. The geometric mean titre was 60 in the sero-converters. The sero-converters were significantly younger than the non-sero-converters (P<0·02) and their mean age was 9·79 months; the mean age of non-sero-converters was 10·1 months. The proportion of non-sero-converters was higher in those who were at least 12 months old than in younger children. It therefore appeared that the low sero-conversion rate was due to other factors in addition to persistent maternal antibodies because the results were the opposite of what would be expected if only maternal antibodies were responsible. It is postulated that vaccine inactivation due to poor storage is an important cause of non-sero-conversion and a plea is made for an effective ‘cold chain’ from the time of vaccine manufacture to its use in the clinics. © 1981 Liverpool School of Tropical Medicine.
Authors & Co-Authors
Ogunmekan, D. A.
Nigeria, Lagos
University of Lagos
Bracken, P.
United Kingdom, Edgware
Edgware Community Hospital
Marshall, W. C.
United Kingdom, London
Hospital for Sick Children
Statistics
Citations: 4
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.1080/00034983.1981.11687412
ISSN:
00034983
e-ISSN:
13648594
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Locations
Nigeria