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immunology and microbiology

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

Immunity, Volume 52, No. 2, Year 2020

Cooperative interactions of monoclonal antibodies (mAbs) with viral antigens are poorly understood. Gilchuk et al. perform structural and functional analysis of cooperativity in a cocktail of two human mAbs, recognizing major epitopes of ebolavirus glycoprotein (GP), and define cooperative binding of the GP as a mechanism for enhanced ebolavirus neutralization.

https://efashare.b-cdn.net/share/pmc/articles/PMC7111202/bin/mmc2.flv

https://efashare.b-cdn.net/share/pmc/articles/PMC7111202/bin/mmc1.pdf

https://efashare.b-cdn.net/share/pmc/articles/PMC7111202/bin/mmc3.pdf

Gilchuk, Pavlo V.
1. United States, Nashville Vanderbilt University Medical Center
Murin, Charles Daniel
1. United States, San Diego Scripps Research Institute
Milligan, Jacob C.
1. United States, San Diego Scripps Research Institute
Cross, Robert W.
1. United States, Galveston Galveston National Laboratory
2. United States, Galveston The University of Texas Medical Branch at Galveston
Mire, Chad E.
1. United States, Galveston Galveston National Laboratory
2. United States, Galveston The University of Texas Medical Branch at Galveston
Ilinykh, Philipp A.
1. United States, Galveston Galveston National Laboratory
2. United States, Galveston University of Texas Medical Branch, School of Medicine
Huang, Kai
1. United States, Galveston Galveston National Laboratory
2. United States, Galveston University of Texas Medical Branch, School of Medicine
Kuzmina, Natalia
1. United States, Galveston Galveston National Laboratory
2. United States, Galveston University of Texas Medical Branch, School of Medicine
Altman, Pilar X.
1. United States, San Diego Scripps Research Institute
Hui, Sean
1. United States, San Diego Scripps Research Institute
Gunn, Bronwyn M.
1. United States, Cambridge Massachusetts Institute of Technology
Bryan, Aubrey
1. United States, Philadelphia Integral Molecular, Inc.
Davidson, Edgar
1. United States, Philadelphia Integral Molecular, Inc.
Doranz, Benjamin J.
1. United States, Philadelphia Integral Molecular, Inc.
Turner, Hannah L.
1. United States, San Diego Scripps Research Institute
Alkutkar, Tanwee
1. United States, San Diego Scripps Research Institute
Flinko, Robin
1. United States, Baltimore University of Maryland School of Medicine
Orlandi, Chiara
1. United States, Baltimore University of Maryland School of Medicine
Carnahan, Robert
1. United States, Nashville Vanderbilt University Medical Center
Nargi, Rachel
1. United States, Nashville Vanderbilt University Medical Center
Bombardi, Robin G.
1. United States, Nashville Vanderbilt University Medical Center
Vodzak, Megan E.
1. United States, Nashville Vanderbilt University Medical Center
Li, Sheng
1. United States, La Jolla University of California, San Diego
Okoli, Adaora
1. Nigeria, Lagos First Consultants Medical Center
Ibeawuchi, Morris
1. Nigeria, Lagos First Consultants Medical Center
Ohiaeri, Benjamin
1. Nigeria, Lagos First Consultants Medical Center
Lewis, George Kenneth
1. United States, Baltimore University of Maryland School of Medicine
Alter, Galit
1. United States, Cambridge Massachusetts Institute of Technology
Bukreyev, Alexander A.
1. United States, Galveston Galveston National Laboratory
2. United States, Galveston The University of Texas Medical Branch at Galveston
3. United States, Galveston University of Texas Medical Branch, School of Medicine
Saphire, Erica Ollmann
1. United States, San Diego Scripps Research Institute
Geisbert, Thomas W.
1. United States, Galveston Galveston National Laboratory
2. United States, Galveston The University of Texas Medical Branch at Galveston
Ward, Andrew B.
1. United States, San Diego Scripps Research Institute
Crowe, James E.
1. United States, Nashville Vanderbilt University Medical Center

AFRICAN RESEARCH NEXUS

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

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African Research Nexus

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AFRICAN RESEARCH NEXUS

Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization

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Disclaimer

African Research Nexus

Useful Links