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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Evaluation of rapid syphilis tests in KwaZulu-Natal
Journal of Clinical Laboratory Analysis, Volume 28, No. 1, Year 2014
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Description
Background: Despite the considerable decrease in the seroprevalence of syphilis in South Africa, with an estimated prevalence of 1.5% in 2010, the disease remains a threat particularly to pregnant women, hence there is a need for a rapid, reliable, and affordable screening and diagnostic test. A laboratory evaluation study was conducted in response to a call by the KwaZulu-Natal (KZN) Provincial Department of Health that is considering using rapid point-of-care syphilis tests. Methods: The performances of the Hexagon and the SD Bioline syphilis tests were compared with the Treponema pallidum hemagglutination assay (TPHA) reference test using 297 (142 positive and 155 negative) serum specimens. Results: Both assays demonstrated good performance with negative and positive concordance of 97 and 94% for the Hexagon assay and 98 and 90% for SD Bioline assay, respectively, when compared to the TPHA. The Hexagon test was quicker and easier to read than the SD Bioline test. Conclusion: Although the rapid syphilis tests performed favorably, a number of issues need to be considered prior to their use for syphilis screening in the public sector of South Africa. © 2014 Wiley Periodicals, Inc.
Authors & Co-Authors
Dlamini, Nomonde Ritta
South Africa, Johannesburg
National Health Laboratory Service
Phili, Rogerio
South Africa, Johannesburg
National Health Laboratory Service
Connolly, Catherine Anne
South Africa, Tygerberg
South African Medical Research Council
Statistics
Citations: 6
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1002/jcla.21647
ISSN:
08878013
e-ISSN:
10982825
Study Design
Cross Sectional Study
Study Locations
South Africa
Participants Gender
Female