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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
A single FLOTAC is more sensitive than triplicate Kato-Katz for the diagnosis of low-intensity soil-transmitted helminth infections
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, No. 4, Year 2009
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Description
Accurate diagnostic tools are pivotal for patient management and surveillance of helminth control programmes, particularly in the current era of preventive chemotherapy. Three consecutive stool samples were obtained from 279 schoolchildren from Zanzibar, an island where anthelminthic drugs have been administered on a large scale for more than a decade. All stool samples were examined with the Kato-Katz method. Additionally, one sample per child was preserved in sodium acetate-acetic acid-formalin solution, and examined with the FLOTAC technique. Considering the pooled results of both methods as diagnostic 'gold' standard, the observed prevalences of Trichuris trichiura, hookworm and Ascaris lumbricoides were 63.4, 35.8 and 22.9%, respectively. The sensitivity of examining a single stool sample by FLOTAC for diagnosing T. trichiura, hookworm and A. lumbricoides was 88.7, 83.0 and 82.8%, respectively. Lower sensitivities were observed for Kato-Katz even after examining three stool samples: 71.8, 46.0 and 70.3%, respectively. Kato-Katz revealed considerably higher infection intensities than FLOTAC. The κ agreement between a single FLOTAC and triplicate Kato-Katz was 0.63 for diagnosing A. lumbricoides and 0.50 for T. trichiura, but only 0.30 for hookworm. The high sensitivity of FLOTAC holds promise for patient management, monitoring soil-transmitted helminth transmission and endpoint(s) of control at the population level. © 2008 Royal Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Knopp, Stefanie
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Rinaldi, Laura
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Khamis, Iddi Simba
Tanzania, Mkokotoni
Ministry of Health Zanzibar
Russell Stothard, John Russell
United Kingdom, London
Biomedical Parasitology Division
Rollinson, D.
United Kingdom, London
Biomedical Parasitology Division
Maurelli, Maria Paola
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Steinmann, Peter
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
China, Beijing
Chinese Center for Disease Control and Prevention
Marti, Hanspeter
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Cringoli, Giuseppe
Italy, Naples
Università Degli Studi Di Napoli Federico Ii
Utzinger, Jürg
Switzerland, Allschwil
Swiss Tropical and Public Health Institute Swiss Tph
Statistics
Citations: 146
Authors: 10
Affiliations: 5
Identifiers
Doi:
10.1016/j.trstmh.2008.11.013
ISSN:
00359203
Research Areas
Cancer
Health System And Policy
Maternal And Child Health
Study Design
Cross Sectional Study