Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies
Cell Death and Disease, Volume 12, No. 1, Article 64, Year 2021
Notification
URL copied to clipboard!
Description
In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series of bioactive products and identified the promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines and cells isolated from patients including the ones derived from tumors resistant to BRAF inhibitors. Moreover, CRO15 was able to decrease viability of cells lines from a broad range of cancer types. This compound acts by two distinct mechanisms. First by activating the AMPK pathway induced by a mitochondrial disorder. Second by inhibition of MELK kinase activity, which induces cell cycle arrest and activation of DNA damage repair pathways by p53 and REDD1 activation. All of these mechanisms activate autophagic and apoptotic processes resulting in melanoma cell death. The strong efficacy of CRO15 to reduce the growth of melanoma xenograft sensitive or resistant to BRAF inhibitors opens interesting perspective. © 2021, The Author(s).
Authors & Co-Authors
Cavazza, Elisa
France, Paris
Inserm
France, Nice
Université Côte D'azur
Ronco, Cyril
France, Nice
Université Côte D'azur
Grytsai, Oleksandr
France, Nice
Université Côte D'azur
Abbe, Patricia
France, Paris
Inserm
France, Nice
Université Côte D'azur
Zerhouni, Marwa
France, Paris
Inserm
France, Nice
Université Côte D'azur
Hofman, Paul M.
France, Nice
Université Côte D'azur
France, Paris
Cnrs Centre National de la Recherche Scientifique
France, Nice
Centre Hospitalier Universitaire de Nice, Hôpital Pasteur
Benhida, Rachid
France, Nice
Université Côte D'azur
Rocchi, Stéphane
France, Paris
Inserm
France, Nice
Université Côte D'azur
Statistics
Citations: 10
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1038/s41419-020-03344-6
ISSN:
20414889
Research Areas
Cancer
Genetics And Genomics